DegronMD - Q8TF30(WHAMM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S665Y	TCGA-BF-AAP4	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation altering degron motif	0.712
p.S665Y	DO219468	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation altering degron motif	0.712
p.R660C	TCGA-CG-5726	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.3056
p.R660C	DO38483	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.3056
p.Q667E	TCGA-Q1-A73O	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.2778
p.Q667E	DO51612	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.2778
p.R660H	TCGA-UC-A7PF	CESC	TCGA	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.3056
p.R660H	DO49987	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.3056
p.R660H	SIDM00697	Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.3056
p.R660H	SIDM01045	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.3056
p.R660H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.3056
p.K68N	SIDM00292	Small Cell Lung Carcinoma	GDSC	KPEAAVSPS	DEG_SIAH_1	68:76	Mutation altering degron motif	0.5806
p.G86A	SIDM01141	Ovarian Carcinoma	GDSC	KPEAAVSPS	DEG_SIAH_1	68:76	Mutation rewiring degron network	0.0556
p.W78C	ACH-000123	Ovarian Cancer	CCLE	KPEAAVSPS	DEG_SIAH_1	68:76	Mutation rewiring degron network	0.2778
p.S663F	ACH-000412	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	661:665	Mutation altering degron motif	0.9093
p.A79S	ACH-000939	Sarcoma	CCLE	KPEAAVSPS	DEG_SIAH_1	68:76	Mutation rewiring degron network	0.25

Kaplan plot for WHAMM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WHAMM

UniProt ID: Q8TF30

Entrez ID: 123720

Protein name: WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WHAMM in