DegronMD

Uniprot ID: Q8TF30

Source protein: WASP homolog-associated protein with actin, membranes and microtubules

Source gene: WHAMM

Class: DEG_SIAH_1

Location: 68:76

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9559

ASA_SCORE: 75.2444

COIL: 0.8163

CONS_SCORE: 0.3461

DSS_SCORE: 0.5708

HELIX: 0.1087

FCONS_SCORE: 0.8448

RIG_SCORE: 0.6412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K68N	SIDM00292	Small Cell Lung Carcinoma	GDSC	KPEAAVSPS	DEG_SIAH_1	0.5806
p.G86A	SIDM01141	Ovarian Carcinoma	GDSC	KPEAAVSPS	DEG_SIAH_1	0.0556
p.W78C	ACH-000123	Ovarian Cancer	CCLE	KPEAAVSPS	DEG_SIAH_1	0.2778
p.A79S	ACH-000939	Sarcoma	CCLE	KPEAAVSPS	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF30	WASP homolog-associated protein with actin, membranes and microtubules	DEG_SIAH_1	68:76	KPEAAVSPS	SIAH1,SIAH2,SIAH3	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons