DegronMD - Q86X51(EZHIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T191M	SIDM02017	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7423
p.P464H	SIDM00455	Pancreatic Carcinoma	GDSC	ISTPSPE	DEG_SCF_FBW7_2	461:467	Mutation altering degron motif	0.7694
p.A58T	SIDM00216	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.3056
p.R180Q	SIDM00967	Ovarian Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.R180Q	SIDM00855	Other Sarcomas	GDSC	ASTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.R180Q	SIDM00971	Breast Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0833
p.S55L	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2222
p.S55L	SIDM00569	Osteosarcoma	GDSC	ALSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2222
p.S55L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2222
p.S55L	SIDM00549	B-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2222
p.G56A	SIDM00287	B-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T191K	SIDM00251	Gastric Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	189:193	Mutation altering degron motif	0.7306
p.G57V	SIDM00537	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2778
p.P451R	SIDM01084	Osteosarcoma	GDSC	ISTPSPE	DEG_SCF_FBW7_2	461:467	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons