DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ISTPSPE
Uniprot ID:
Q86X51
Source protein:
EZH inhibitory protein
Source gene:
EZHIP
Class:
DEG_SCF_FBW7_2
Location:
461:467
E3 ligase:
FBXW7
DEGRON score:
0.9996
ASA_SCORE:
79.8286
COIL:
0.8843
CONS_SCORE:
0.9185
DSS_SCORE:
0.4148
HELIX:
0.0703
FCONS_SCORE:
1.2521
RIG_SCORE:
0.6318
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P464H
SIDM00455
Pancreatic Carcinoma
GDSC
ISTPSPE
DEG_SCF_FBW7_2
0.7694
p.P451R
SIDM01084
Osteosarcoma
GDSC
ISTPSPE
DEG_SCF_FBW7_2
0.0556
Drug responses associated with EZHIP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISTPSPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86X51
EZH inhibitory protein
DEG_SCF_FBW7_2
461:467
ISTPSPE
FBXW7
0.9996
More...