DegronMD - Q4KWH8(PLCH1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1254L	TCGA-5L-AAT1	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.1667
p.S420F	TCGA-77-7140	LUSC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation altering degron motif	0.7982
p.D991Y	TCGA-A5-A1OF	UCEC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.0833
p.D991Y	TCGA-A5-A1OF	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.25
p.D991Y	TCGA-EO-A3AY	UCEC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.0833
p.D991Y	TCGA-EO-A3AY	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.25
p.S434N	TCGA-AH-6643	READ	TCGA	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0833
p.P1256L	TCGA-BG-A0VZ	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.2222
p.P1256L	TCGA-EB-A5UL	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.2222
p.I992N	TCGA-BR-7707	STAD	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.0556
p.I992N	TCGA-BR-7707	STAD	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2778
p.A1000P	TCGA-CG-5717	STAD	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2778
p.E993K	TCGA-CN-5374	HNSC	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.3056
p.A1000T	TCGA-CV-6935	HNSC	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2778
p.A1000T	TCGA-EE-A2A6	SKCM	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2778
p.K1268Q	TCGA-EO-A3AV	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation substituting flanking lysine	0.3333
p.K1003T	TCGA-EY-A1G8	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation substituting flanking lysine	0.3056
p.R967H	TCGA-EY-A549	UCEC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1389
p.G410E	TCGA-FS-A4F5	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.L977F	TCGA-FW-A3R5	SKCM	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation altering degron motif	0.587
p.N976S	TCGA-FW-A3R5	SKCM	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation altering degron motif	0.5958
p.R975K	TCGA-JX-A3Q0	CESC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation altering degron motif	0.7237
p.E425Q	TCGA-MA-AA41	CESC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation altering degron motif	0.6744
p.H1269P	TCGA-QB-AA9O	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.1944
p.G433R	DO219041	BLCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.1111
p.R1274S	DO52602	BOCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.0556
p.R969T	DO1094	BRCA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1944
p.A1257G	DO1297	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.25
p.R1274H	DO4617	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.0556
p.R1274H	DO43186	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.0556
p.G1268E	DO49935	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation substituting flanking lysine	0.3333
p.G1268E	DO51273	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation substituting flanking lysine	0.3333
p.G1268R	DO49935	CESC	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation substituting flanking lysine	0.3333
p.A1257T	DO9002	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.25
p.S1264I	DO230326	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation altering degron motif	0.7341
p.A1257V	DO10880	GBM	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.25
p.V1006L	DO15270	HNSC	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1111
p.I1005V	DO22716	LGG	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.L995P	DO22159	LGG	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation altering degron motif	0.7582
p.V1000A	DO228949	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2778
p.N984K	DO228976	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.2778
p.N984K	DO228976	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.0556
p.N984K	DO229026	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.2778
p.N984K	DO229026	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.0556
p.P986Q	DO229028	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.2222
p.P986Q	DO229028	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1111
p.F999L	DO229035	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.3056
p.F999L	SIDM00971	Breast Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.3056
p.F999L	SIDM00673	Breast Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.3056
p.T987N	DO229045	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1944
p.T987N	DO229045	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.G1002R	DO48486	LIHC	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2222
p.G1002R	DO45357	LUAD	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2222
p.G1002R	DO48665	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2222
p.N984I	DO23750	LUAD	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.2778
p.N984I	DO23750	LUAD	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.0556
p.C1005W	DO230950	LUSC	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.C1005W	DO224638	LUSC	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.H431Q	DO231078	LUSC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.1667
p.M994I	DO229122	NKTL	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation altering degron motif	0.7618
p.C995Y	DO232761	PBCA	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation altering degron motif	0.7087
p.S416N	DO36591	READ	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.2222
p.S1269F	DO37567	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.1944
p.S1269F	MZ7-mel	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.1944
p.H431Y	DO37734	SKCM	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.1667
p.G1002E	DO48665	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2222
p.G971E	DO47368	SKCM	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.25
p.S1273F	DO51246	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.0833
p.A993V	DO38123	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.3056
p.L432I	DO219456	SKCM	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.1389
p.L987S	DO38887	STAD	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1944
p.L987S	DO38887	STAD	ICGC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.A1257D	DO38404	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.25
p.L417S	DO229248	THCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.25
p.K965T	DO43578	UCEC	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.0833
p.G425S	DO42793	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation altering degron motif	0.6993
p.G433E	DO42793	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.1111
p.A973S	DO42713	UCEC	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.3056
p.G410R	SIDM00586	Hepatocellular Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM00373	Endometrial Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM00315	Glioblastoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM01005	Acute Myeloid Leukemia	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM00465	Ovarian Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM00214	Colorectal Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM00997	Thyroid Gland Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.G410R	SIDM00989	Bladder Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation rewiring degron network	0.0556
p.D980E	SIDM00773	Non-Cancerous	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation altering degron motif	0.6758
p.D980E	SIDM01265	Plasma Cell Myeloma	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation altering degron motif	0.6758
p.E987K	SIDM01175	Other Sarcomas	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1944
p.E987K	SIDM01175	Other Sarcomas	GDSC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.E987K	ACH-002309	Sarcoma	CCLE	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1944
p.E987K	ACH-002309	Sarcoma	CCLE	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.E987K	SW684	soft tissue	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1944
p.E987K	SW684	soft tissue	COSMIC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1389
p.I992T	SIDM00650	Small Cell Lung Carcinoma	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.0556
p.I992T	SIDM00650	Small Cell Lung Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2778
p.I992T	SIDM01681	Non-Cancerous	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.0556
p.I992T	SIDM01681	Non-Cancerous	GDSC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.2778
p.L1261P	SIDM00333	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation altering degron motif	0.6471
p.L1261P	ACH-000988	Endometrial/Uterine Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation altering degron motif	0.6471
p.L1261P	MFE-319	endometrium	COSMIC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation altering degron motif	0.6471
p.G424A	SIDM00054	Pancreatic Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation altering degron motif	0.754
p.G424A	ACH-001619	Gallbladder Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation altering degron motif	0.754
p.G424A	ACH-002185	Pancreatic Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation altering degron motif	0.754
p.G424A	PL18	pancreas	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	420:425	Mutation altering degron motif	0.754
p.R1006S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1111
p.R1006S	ACH-000637	Esophageal Cancer	CCLE	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1111
p.R1006S	KYSE-520	oesophagus	COSMIC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.1111
p.R968S	KYSE-520	oesophagus	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1667
p.D977N	MDST8	large intestine	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation altering degron motif	0.6932
p.L1253P	MFE-319	endometrium	COSMIC	ALSSS	DEG_SPOP_SBC_1	1260:1264	Mutation rewiring degron network	0.1389
p.D1007N	MDST8	large intestine	COSMIC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation rewiring degron network	0.0833
p.E979K	SW684	soft tissue	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation altering degron motif	0.7022
p.E967K	SW684	soft tissue	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	974:982	Mutation rewiring degron network	0.1389
p.R998S	KYSE-520	oesophagus	COSMIC	GKENS	DEG_APCC_KENBOX_2	994:998	Mutation altering degron motif	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCH1

UniProt ID: Q4KWH8

Entrez ID: 23007

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLCH1 in