DegronMD

Uniprot ID: Q4KWH8

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Source gene: PLCH1

Class: DEG_APCC_DBOX_1

Location: 974:982

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 79.7556

COIL: 0.7076

CONS_SCORE: 0.329

DSS_SCORE: 0.4277

HELIX: 0.2549

FCONS_SCORE: 1.0038

RIG_SCORE: 0.7525

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D991Y	TCGA-A5-A1OF	UCEC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	0.0833
p.D991Y	TCGA-EO-A3AY	UCEC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	0.0833
p.I992N	TCGA-BR-7707	STAD	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	0.0556
p.R967H	TCGA-EY-A549	UCEC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	0.1389
p.L977F	TCGA-FW-A3R5	SKCM	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	0.587
p.N976S	TCGA-FW-A3R5	SKCM	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	0.5958
p.R975K	TCGA-JX-A3Q0	CESC	TCGA	DRNLLGALS	DEG_APCC_DBOX_1	0.7237
p.R969T	DO1094	BRCA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.1944
p.N984K	DO228976	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.2778
p.N984K	DO229026	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.2778
p.P986Q	DO229028	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.2222
p.T987N	DO229045	LICA	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.1944
p.N984I	DO23750	LUAD	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.2778
p.G971E	DO47368	SKCM	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.25
p.L987S	DO38887	STAD	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.1944
p.K965T	DO43578	UCEC	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.0833
p.A973S	DO42713	UCEC	ICGC	DRNLLGALS	DEG_APCC_DBOX_1	0.3056
p.D980E	SIDM00773	Non-Cancerous	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	0.6758
p.D980E	SIDM01265	Plasma Cell Myeloma	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	0.6758
p.E987K	SIDM01175	Other Sarcomas	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	0.1944
p.E987K	ACH-002309	Sarcoma	CCLE	DRNLLGALS	DEG_APCC_DBOX_1	0.1944
p.E987K	SW684	soft_tissue	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	0.1944
p.I992T	SIDM00650	Small Cell Lung Carcinoma	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	0.0556
p.I992T	SIDM01681	Non-Cancerous	GDSC	DRNLLGALS	DEG_APCC_DBOX_1	0.0556
p.R968S	KYSE-520	oesophagus	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	0.1667
p.D977N	MDST8	large_intestine	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	0.6932
p.E979K	SW684	soft_tissue	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	0.7022
p.E967K	SW684	soft_tissue	COSMIC	DRNLLGALS	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRNLLGALS

Degron related mutations and impact score

Drug responses associated with PLCH1 mutations

All proteins holding degron of DRNLLGALS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_APCC_DBOX_1	974:982	DRNLLGALS	APC,CDC20,FZR1	0.9974	More...