DegronMD

Uniprot ID: Q4KWH8

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Source gene: PLCH1

Class: DEG_APCC_KENBOX_2

Location: 994:998

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6486

ASA_SCORE: 87.04

COIL: 0.7092

CONS_SCORE: 0.3164

DSS_SCORE: 0.5803

HELIX: 0.2392

FCONS_SCORE: 1.0216

RIG_SCORE: 0.6893

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D991Y	TCGA-A5-A1OF	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.25
p.D991Y	TCGA-EO-A3AY	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.25
p.I992N	TCGA-BR-7707	STAD	TCGA	GKENS	DEG_APCC_KENBOX_2	0.2778
p.A1000P	TCGA-CG-5717	STAD	TCGA	GKENS	DEG_APCC_KENBOX_2	0.2778
p.E993K	TCGA-CN-5374	HNSC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.3056
p.A1000T	TCGA-CV-6935	HNSC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.2778
p.A1000T	TCGA-EE-A2A6	SKCM	TCGA	GKENS	DEG_APCC_KENBOX_2	0.2778
p.K1003T	TCGA-EY-A1G8	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.3056
p.V1006L	DO15270	HNSC	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1111
p.I1005V	DO22716	LGG	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.L995P	DO22159	LGG	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7582
p.V1000A	DO228949	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.2778
p.N984K	DO228976	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.N984K	DO229026	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.P986Q	DO229028	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1111
p.F999L	DO229035	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.F999L	SIDM00971	Breast Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.F999L	SIDM00673	Breast Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.T987N	DO229045	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.G1002R	DO48486	LIHC	ICGC	GKENS	DEG_APCC_KENBOX_2	0.2222
p.G1002R	DO45357	LUAD	ICGC	GKENS	DEG_APCC_KENBOX_2	0.2222
p.G1002R	DO48665	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	0.2222
p.N984I	DO23750	LUAD	ICGC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.C1005W	DO230950	LUSC	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.C1005W	DO224638	LUSC	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.M994I	DO229122	NKTL	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7618
p.C995Y	DO232761	PBCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7087
p.G1002E	DO48665	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	0.2222
p.A993V	DO38123	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.L987S	DO38887	STAD	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.E987K	SIDM01175	Other Sarcomas	GDSC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.E987K	ACH-002309	Sarcoma	CCLE	GKENS	DEG_APCC_KENBOX_2	0.1389
p.E987K	SW684	soft_tissue	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.I992T	SIDM00650	Small Cell Lung Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.2778
p.I992T	SIDM01681	Non-Cancerous	GDSC	GKENS	DEG_APCC_KENBOX_2	0.2778
p.R1006S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.1111
p.R1006S	ACH-000637	Esophageal Cancer	CCLE	GKENS	DEG_APCC_KENBOX_2	0.1111
p.R1006S	KYSE-520	oesophagus	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.1111
p.D1007N	MDST8	large_intestine	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.0833
p.R998S	KYSE-520	oesophagus	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27448	MAP/microtubule affinity-regulating kinase 3	DEG_APCC_KENBOX_2	525:529	GKENS	APC,CDC20,FZR1	0.6336	More...
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_APCC_KENBOX_2	994:998	GKENS	APC,CDC20,FZR1	0.6486	More...
Q8TCG5	Carnitine O-palmitoyltransferase 1, brain isoform	DEG_APCC_KENBOX_2	776:780	GKENS	APC,CDC20,FZR1	0.5545	More...
Q9NZJ0	Denticleless protein homolog	DEG_APCC_KENBOX_2	651:655	GKENS	APC,CDC20,FZR1	0.9981	More...
Q96T92	Insulinoma-associated protein 2	DEG_APCC_KENBOX_2	353:357	GKENS	APC,CDC20,FZR1	0.8158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENS

Degron related mutations and impact score

Drug responses associated with PLCH1 mutations

All proteins holding degron of GKENS