DegronMD

Uniprot ID: Q8TCG5

Source protein: Carnitine O-palmitoyltransferase 1, brain isoform

Source gene: CPT1C

Class: DEG_APCC_KENBOX_2

Location: 776:780

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5545

ASA_SCORE: 95.28

COIL: 0.8216

CONS_SCORE: 0.3648

DSS_SCORE: 0.48

HELIX: 0.1388

FCONS_SCORE: 0.9833

RIG_SCORE: 0.6172

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H767N	TCGA-AX-A2HC	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.0833
p.H767N	DO41572	UCEC	ICGC	GKENS	DEG_APCC_KENBOX_2	0.0833
p.E778V	TCGA-BB-7870	HNSC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.7693
p.E778V	DO14378	HNSC	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7693
p.R770H	TCGA-D3-A1Q5	SKCM	TCGA	GKENS	DEG_APCC_KENBOX_2	0.1667
p.R770H	DO37827	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1667
p.E778K	TCGA-GN-A265	SKCM	TCGA	GKENS	DEG_APCC_KENBOX_2	0.7022
p.E778K	DO37491	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7022
p.R770C	TCGA-VQ-A8PB	STAD	TCGA	GKENS	DEG_APCC_KENBOX_2	0.1667
p.R770C	DO51766	STAD	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1667
p.E778D	DO222884	COCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.6758
p.E778D	SIDM01141	Ovarian Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.6758
p.E778D	SIDM00684	Glioblastoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.6758
p.E778D	LN-229	central_nervous_system	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.6758
p.E778D	OV-90	ovary	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.6758
p.G776E	DO229036	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.6087
p.G776E	DO218861	SKCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.6087
p.G776W	DO229038	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.6714
p.R789C	DO23551	LIRI	ICGC	GKENS	DEG_APCC_KENBOX_2	0.0833
p.F772I	DO51517	PACA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.2222
p.Q766L	SIDM01119	Other Solid Cancers	GDSC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.Q766L	ACH-000775	Lung Cancer	CCLE	GKENS	DEG_APCC_KENBOX_2	0.0556
p.Q766L	NCI-H727	lung	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.S775P	SIDM00214	Colorectal Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.S775P	ACH-000955	Colon/Colorectal Cancer	CCLE	GKENS	DEG_APCC_KENBOX_2	0.3056
p.S775P	SNU-407	large_intestine	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.G774V	ACH-000229	Non-Cancerous	CCLE	GKENS	DEG_APCC_KENBOX_2	0.2778
p.E767D	LN-229	central_nervous_system	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.0833
p.E767D	OV-90	ovary	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27448	MAP/microtubule affinity-regulating kinase 3	DEG_APCC_KENBOX_2	525:529	GKENS	APC,CDC20,FZR1	0.6336	More...
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_APCC_KENBOX_2	994:998	GKENS	APC,CDC20,FZR1	0.6486	More...
Q8TCG5	Carnitine O-palmitoyltransferase 1, brain isoform	DEG_APCC_KENBOX_2	776:780	GKENS	APC,CDC20,FZR1	0.5545	More...
Q9NZJ0	Denticleless protein homolog	DEG_APCC_KENBOX_2	651:655	GKENS	APC,CDC20,FZR1	0.9981	More...
Q96T92	Insulinoma-associated protein 2	DEG_APCC_KENBOX_2	353:357	GKENS	APC,CDC20,FZR1	0.8158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENS

Degron related mutations and impact score

Drug responses associated with CPT1C mutations

All proteins holding degron of GKENS