DegronMD - P27448(MARK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W306L	TCGA-D3-A1Q6	SKCM	TCGA	LKPFVE	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.0556
p.W306L	DO37450	SKCM	ICGC	LKPFVE	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.0556
p.T19R	TCGA-V1-A9Z9	PRAD	TCGA	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1111
p.T19R	DO219395	PRAD	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1111
p.N11K	TCGA-VQ-A91U	STAD	TCGA	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.5806
p.N11K	DO51787	STAD	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.5806
p.S20P	DO225013	BRCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.S20P	DO52557	BRCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.T3N	DO225278	BRCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7055
p.S20L	DO223041	ESCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0833
p.A309S	DO231937	LICA	ICGC	LKPFVE	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.1389
p.L7F	DO228948	LICA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6981
p.A539S	DO228952	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	525:529	Mutation rewiring degron network	0.0556
p.A516T	SIDM00557	Neuroblastoma	GDSC	GKENS	DEG_APCC_KENBOX_2	525:529	Mutation rewiring degron network	0.0833
p.A516T	ACH-000345	Neuroblastoma	CCLE	GKENS	DEG_APCC_KENBOX_2	525:529	Mutation rewiring degron network	0.0833
p.A516T	KP-N-RT-BM-1	autonomic ganglia	COSMIC	GKENS	DEG_APCC_KENBOX_2	525:529	Mutation rewiring degron network	0.0833
p.R318H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	LKPFVE	LIG_APCC_ABBA_1	316:321	Mutation altering degron motif	0.8244
p.A539T	KP-N-RT-BM-1	autonomic ganglia	COSMIC	GKENS	DEG_APCC_KENBOX_2	525:529	Mutation rewiring degron network	0.0556
p.S317I	JHH-7	liver	COSMIC	LKPFVE	LIG_APCC_ABBA_1	316:321	Mutation altering degron motif	0.7341
p.R309T	HT-1376	urinary tract	COSMIC	LKPFVE	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.1389
p.S522A	MDA-MB-468	breast	COSMIC	GKENS	DEG_APCC_KENBOX_2	525:529	Mutation rewiring degron network	0.25

Kaplan plot for MARK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MARK3

UniProt ID: P27448

Entrez ID: 4140

Protein name: MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MARK3 in