DegronMD

Uniprot ID: P27448

Source protein: MAP/microtubule affinity-regulating kinase 3

Source gene: MARK3

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 107.4778

COIL: 0.9721

CONS_SCORE: 0.3127

DSS_SCORE: 0.8851

HELIX: 0.0144

FCONS_SCORE: 1.2093

RIG_SCORE: 0.6636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T19R	TCGA-V1-A9Z9	PRAD	TCGA	TRTPLPTVN	DEG_APCC_DBOX_1	0.1111
p.T19R	DO219395	PRAD	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	0.1111
p.N11K	TCGA-VQ-A91U	STAD	TCGA	TRTPLPTVN	DEG_APCC_DBOX_1	0.5806
p.N11K	DO51787	STAD	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	0.5806
p.S20P	DO225013	BRCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	0.0833
p.S20P	DO52557	BRCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	0.0833
p.T3N	DO225278	BRCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	0.7055
p.S20L	DO223041	ESCA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	0.0833
p.L7F	DO228948	LICA	ICGC	TRTPLPTVN	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27448	MAP/microtubule affinity-regulating kinase 3	DEG_APCC_DBOX_1	3:11	TRTPLPTVN	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons