DegronMD

Uniprot ID: P27448

Source protein: MAP/microtubule affinity-regulating kinase 3

Source gene: MARK3

Class: DEG_APCC_KENBOX_2

Location: 525:529

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6336

ASA_SCORE: 95.76

COIL: 0.8976

CONS_SCORE: 0.2824

DSS_SCORE: 0.6749

HELIX: 0.0482

FCONS_SCORE: 0.9586

RIG_SCORE: 0.6465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A539S	DO228952	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.A516T	SIDM00557	Neuroblastoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.0833
p.A516T	ACH-000345	Neuroblastoma	CCLE	GKENS	DEG_APCC_KENBOX_2	0.0833
p.A516T	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.0833
p.A539T	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.S522A	MDA-MB-468	breast	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27448	MAP/microtubule affinity-regulating kinase 3	DEG_APCC_KENBOX_2	525:529	GKENS	APC,CDC20,FZR1	0.6336	More...
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_APCC_KENBOX_2	994:998	GKENS	APC,CDC20,FZR1	0.6486	More...
Q8TCG5	Carnitine O-palmitoyltransferase 1, brain isoform	DEG_APCC_KENBOX_2	776:780	GKENS	APC,CDC20,FZR1	0.5545	More...
Q9NZJ0	Denticleless protein homolog	DEG_APCC_KENBOX_2	651:655	GKENS	APC,CDC20,FZR1	0.9981	More...
Q96T92	Insulinoma-associated protein 2	DEG_APCC_KENBOX_2	353:357	GKENS	APC,CDC20,FZR1	0.8158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons