DegronMD

Uniprot ID: Q9NZJ0

Source protein: Denticleless protein homolog

Source gene: DTL

Class: DEG_APCC_KENBOX_2

Location: 651:655

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9981

ASA_SCORE: 74.72

COIL: 0.8308

CONS_SCORE: 0.422

DSS_SCORE: 0.5957

HELIX: 0.0698

FCONS_SCORE: 1.0646

RIG_SCORE: 0.6324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E648Q	TCGA-AJ-A3QS	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	0.25
p.G651D	TCGA-G4-6304	COAD	TCGA	GKENS	DEG_APCC_KENBOX_2	0.6087
p.G650E	DO1076	BRCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.K652T	DO229010	COCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7306
p.K652T	DO229013	COCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7306
p.K652T	DO229016	COCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7306
p.K652T	DO229003	COCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7306
p.K652T	DO229005	COCA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.7306
p.S662I	DO228948	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.N644K	DO232846	NACA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1389
p.P643T	DO233293	NACA	ICGC	GKENS	DEG_APCC_KENBOX_2	0.1111
p.G650R	DO38427	STAD	ICGC	GKENS	DEG_APCC_KENBOX_2	0.3056
p.P656L	DO40978	UCEC	ICGC	GKENS	DEG_APCC_KENBOX_2	0.75
p.A665V	SIDM00572	Gastric Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.0556
p.A665V	ACH-000911	Gastric Cancer	CCLE	GKENS	DEG_APCC_KENBOX_2	0.0556
p.A665V	NUGC-3	stomach	COSMIC	GKENS	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27448	MAP/microtubule affinity-regulating kinase 3	DEG_APCC_KENBOX_2	525:529	GKENS	APC,CDC20,FZR1	0.6336	More...
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_APCC_KENBOX_2	994:998	GKENS	APC,CDC20,FZR1	0.6486	More...
Q8TCG5	Carnitine O-palmitoyltransferase 1, brain isoform	DEG_APCC_KENBOX_2	776:780	GKENS	APC,CDC20,FZR1	0.5545	More...
Q9NZJ0	Denticleless protein homolog	DEG_APCC_KENBOX_2	651:655	GKENS	APC,CDC20,FZR1	0.9981	More...
Q96T92	Insulinoma-associated protein 2	DEG_APCC_KENBOX_2	353:357	GKENS	APC,CDC20,FZR1	0.8158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons