DegronMD

Uniprot ID: Q96T92

Source protein: Insulinoma-associated protein 2

Source gene: INSM2

Class: DEG_APCC_KENBOX_2

Location: 353:357

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8158

ASA_SCORE: 84.76

COIL: 0.7576

CONS_SCORE: 0.2323

DSS_SCORE: 0.6315

HELIX: 0.093

FCONS_SCORE: 1.0165

RIG_SCORE: 0.6359

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I359K	DO51953	PRAD	ICGC	GKENS	DEG_APCC_KENBOX_2	0.2778
p.A363V	SIDM00475	Ovarian Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.1667
p.A363V	SIDM00098	Mesothelioma	GDSC	GKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27448	MAP/microtubule affinity-regulating kinase 3	DEG_APCC_KENBOX_2	525:529	GKENS	APC,CDC20,FZR1	0.6336	More...
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_APCC_KENBOX_2	994:998	GKENS	APC,CDC20,FZR1	0.6486	More...
Q8TCG5	Carnitine O-palmitoyltransferase 1, brain isoform	DEG_APCC_KENBOX_2	776:780	GKENS	APC,CDC20,FZR1	0.5545	More...
Q9NZJ0	Denticleless protein homolog	DEG_APCC_KENBOX_2	651:655	GKENS	APC,CDC20,FZR1	0.9981	More...
Q96T92	Insulinoma-associated protein 2	DEG_APCC_KENBOX_2	353:357	GKENS	APC,CDC20,FZR1	0.8158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons