DegronMD - Q96T92(INSM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E424D	TCGA-AG-A002	READ	TCGA	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1667
p.A322T	TCGA-BR-8382	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.0556
p.A322T	DO232761	PBCA	ICGC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.0556
p.A322T	DO47925	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.0556
p.R341L	TCGA-DA-A1I1	SKCM	TCGA	DSGAIAS	DEG_SCF_TRCP1_1	342:348	Mutation rewiring degron network	0.3056
p.R341L	TCGA-DA-A1I1	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1944
p.R341L	DO37966	SKCM	ICGC	DSGAIAS	DEG_SCF_TRCP1_1	342:348	Mutation rewiring degron network	0.3056
p.R341L	DO37966	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1944
p.V411L	DO229028	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.25
p.G330R	DO51965	PRAD	ICGC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.G330R	SIDM01113	Other Sarcomas	GDSC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.G330R	ACH-000939	Sarcoma	CCLE	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.G330R	SK-UT-1	soft tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.I359K	DO51953	PRAD	ICGC	GKENS	DEG_APCC_KENBOX_2	353:357	Mutation rewiring degron network	0.2778
p.P414S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6752
p.P414S	SIDM00773	Non-Cancerous	GDSC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6752
p.P414S	SIDM01117	Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6752
p.P414S	SIDM00087	Plasma Cell Myeloma	GDSC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6752
p.P414S	SIDM00690	Head and Neck Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6752
p.P414S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6752
p.A363V	SIDM00475	Ovarian Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	353:357	Mutation rewiring degron network	0.1667
p.A363V	SIDM00098	Mesothelioma	GDSC	GKENS	DEG_APCC_KENBOX_2	353:357	Mutation rewiring degron network	0.1667
p.S338L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	DSGAIAS	DEG_SCF_TRCP1_1	342:348	Mutation rewiring degron network	0.2222
p.S338L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.S338L	ACH-000841	Lung Cancer	CCLE	DSGAIAS	DEG_SCF_TRCP1_1	342:348	Mutation rewiring degron network	0.2222
p.S338L	ACH-000841	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.S338L	NCI-H2087	lung	COSMIC	DSGAIAS	DEG_SCF_TRCP1_1	342:348	Mutation rewiring degron network	0.2222
p.S338L	NCI-H2087	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.2778
p.K331E	SIDM00217	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.3056
p.K331E	ACH-000999	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.3056
p.K331E	SNU-1040	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.3056
p.S327F	ACH-002710	Sarcoma	CCLE	PPSSS	DEG_SPOP_SBC_1	332:336	Mutation rewiring degron network	0.1944
p.V406G	Hs939-T	skin	COSMIC	PGSTS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1111

Kaplan plot for INSM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INSM2

UniProt ID: Q96T92

Entrez ID: 84684

Protein name: Insulinoma-associated protein 2 (Zinc finger protein IA-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INSM2 in