DegronMD

Uniprot ID: Q96T92

Source protein: Insulinoma-associated protein 2

Source gene: INSM2

Class: DEG_SCF_TRCP1_1

Location: 342:348

E3 ligase: BTRC

DEGRON score: 0.9787

ASA_SCORE: 62.3

COIL: 0.7526

CONS_SCORE: 0.1559

DSS_SCORE: 0.608

HELIX: 0.1169

FCONS_SCORE: 0.7059

RIG_SCORE: 0.6253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R341L	TCGA-DA-A1I1	SKCM	TCGA	DSGAIAS	DEG_SCF_TRCP1_1	0.3056
p.R341L	DO37966	SKCM	ICGC	DSGAIAS	DEG_SCF_TRCP1_1	0.3056
p.S338L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	DSGAIAS	DEG_SCF_TRCP1_1	0.2222
p.S338L	ACH-000841	Lung Cancer	CCLE	DSGAIAS	DEG_SCF_TRCP1_1	0.2222
p.S338L	NCI-H2087	lung	COSMIC	DSGAIAS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T92	Insulinoma-associated protein 2	DEG_SCF_TRCP1_1	342:348	DSGAIAS	BTRC	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons