DegronMD - Q8TCG5(CPT1C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H767N	TCGA-AX-A2HC	UCEC	TCGA	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0833
p.H767N	DO41572	UCEC	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0833
p.E778V	TCGA-BB-7870	HNSC	TCGA	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.7693
p.E778V	DO14378	HNSC	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.7693
p.R770H	TCGA-D3-A1Q5	SKCM	TCGA	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.1667
p.R770H	DO37827	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.1667
p.E778K	TCGA-GN-A265	SKCM	TCGA	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.7022
p.E778K	DO37491	SKCM	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.7022
p.R770C	TCGA-VQ-A8PB	STAD	TCGA	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.1667
p.R770C	DO51766	STAD	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.1667
p.E778D	DO222884	COCA	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6758
p.E778D	SIDM01141	Ovarian Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6758
p.E778D	SIDM00684	Glioblastoma	GDSC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6758
p.E778D	LN-229	central nervous system	COSMIC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6758
p.E778D	OV-90	ovary	COSMIC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6758
p.G776E	DO229036	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6087
p.G776E	DO218861	SKCA	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6087
p.G776W	DO229038	LICA	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation altering degron motif	0.6714
p.R789C	DO23551	LIRI	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0833
p.F772I	DO51517	PACA	ICGC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.2222
p.Q766L	SIDM01119	Other Solid Cancers	GDSC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0556
p.Q766L	ACH-000775	Lung Cancer	CCLE	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0556
p.Q766L	NCI-H727	lung	COSMIC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0556
p.S775P	SIDM00214	Colorectal Carcinoma	GDSC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.3056
p.S775P	ACH-000955	Colon/Colorectal Cancer	CCLE	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.3056
p.S775P	SNU-407	large intestine	COSMIC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.3056
p.G774V	ACH-000229	Non-Cancerous	CCLE	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.2778
p.E767D	LN-229	central nervous system	COSMIC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0833
p.E767D	OV-90	ovary	COSMIC	GKENS	DEG_APCC_KENBOX_2	776:780	Mutation rewiring degron network	0.0833

Kaplan plot for CPT1C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPT1C

UniProt ID: Q8TCG5

Entrez ID: 126129

Protein name: Carnitine O-palmitoyltransferase 1, brain isoform (CPT1-B) (EC 2.3.1.21) (CPT IC) (Carnitine O-palmitoyltransferase I, brain isoform) (CPTI-B) (Carnitine palmitoyltransferase 1C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPT1C in