DegronMD

Uniprot ID: P27448

Source protein: MAP/microtubule affinity-regulating kinase 3

Source gene: MARK3

Class: LIG_APCC_ABBA_1

Location: 316:321

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8092

ASA_SCORE: 91.0333

COIL: 0.9158

CONS_SCORE: 0.4582

DSS_SCORE: 0.4859

HELIX: 0.0452

FCONS_SCORE: 1.0909

RIG_SCORE: 0.7873

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R318H	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	LKPFVE	LIG_APCC_ABBA_1	0.8244
p.S317I	JHH-7	liver	COSMIC	LKPFVE	LIG_APCC_ABBA_1	0.7341
p.A309S	DO231937	LICA	ICGC	LKPFVE	LIG_APCC_ABBA_1	0.1389
p.R309T	HT-1376	urinary_tract	COSMIC	LKPFVE	LIG_APCC_ABBA_1	0.1389
p.W306L	TCGA-D3-A1Q6	SKCM	TCGA	LKPFVE	LIG_APCC_ABBA_1	0.0556
p.W306L	DO37450	SKCM	ICGC	LKPFVE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27448	MAP/microtubule affinity-regulating kinase 3	LIG_APCC_ABBA_1	316:321	LKPFVE	APC,CDC20,FZR1	0.8092	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons