DegronMD

Uniprot ID: Q4KWH8

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Source gene: PLCH1

Class: DEG_Kelch_Keap1_1

Location: 420:425

E3 ligase: KEAP1

DEGRON score: 0.7587

ASA_SCORE: 75.7167

COIL: 0.8648

CONS_SCORE: 0.4702

DSS_SCORE: 0.3734

HELIX: 0.0655

FCONS_SCORE: 0.7453

RIG_SCORE: 0.7456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S420F	TCGA-77-7140	LUSC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7982
p.S434N	TCGA-AH-6643	READ	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.0833
p.G410E	TCGA-FS-A4F5	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.E425Q	TCGA-MA-AA41	CESC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.6744
p.G433R	DO219041	BLCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.1111
p.H431Q	DO231078	LUSC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.1667
p.S416N	DO36591	READ	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.2222
p.H431Y	DO37734	SKCM	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.1667
p.L432I	DO219456	SKCM	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.1389
p.L417S	DO229248	THCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.25
p.G425S	DO42793	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.6993
p.G433E	DO42793	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.1111
p.G410R	SIDM00586	Hepatocellular Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM00373	Endometrial Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM00315	Glioblastoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM01005	Acute Myeloid Leukemia	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM00465	Ovarian Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM00214	Colorectal Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM00997	Thyroid Gland Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G410R	SIDM00989	Bladder Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.G424A	SIDM00054	Pancreatic Carcinoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.754
p.G424A	ACH-001619	Gallbladder Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	0.754
p.G424A	ACH-002185	Pancreatic Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	0.754
p.G424A	PL18	pancreas	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_Kelch_Keap1_1	420:425	SVDTGE	KEAP1	0.7587	More...
Q9UPY3	Endoribonuclease Dicer	DEG_Kelch_Keap1_1	593:598	SVDTGE	KEAP1	0.744	More...
Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	DEG_Kelch_Keap1_1	1362:1367	SVDTGE	KEAP1	0.8216	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SVDTGE

Degron related mutations and impact score

Drug responses associated with PLCH1 mutations

All proteins holding degron of SVDTGE