DegronMD - Q9UPY3(DICER1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1386A	TCGA-A5-A0G2	UCEC	TCGA	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.3056
p.V1386A	DO41235	UCEC	ICGC	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.3056
p.R1898M	TCGA-AX-A2HD	UCEC	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation rewiring degron network	0.1389
p.R1898M	DO42608	UCEC	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation rewiring degron network	0.1389
p.R1910Q	TCGA-B5-A1MR	UCEC	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation altering degron motif	0.6218
p.R1910Q	DO222798	COCA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation altering degron motif	0.6218
p.R1910Q	DO50917	LICA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation altering degron motif	0.6218
p.R1910Q	DO41758	UCEC	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation altering degron motif	0.6218
p.D600E	TCGA-CR-7402	HNSC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation rewiring degron network	0.2778
p.D600E	DO15727	HNSC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation rewiring degron network	0.2778
p.S593L	TCGA-D8-A1JG	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation altering degron motif	0.7667
p.S593L	DO1256	BRCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation altering degron motif	0.7667
p.S1902F	TCGA-D9-A6EC	SKCM	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation rewiring degron network	0.25
p.S1902F	DO50291	SKCM	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation rewiring degron network	0.25
p.S591C	TCGA-E9-A244	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation rewiring degron network	0.2778
p.S591C	DO5263	BRCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation rewiring degron network	0.2778
p.R1906S	TCGA-EM-A2CT	THCA	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation altering degron motif	0.7427
p.R1906S	DO39198	THCA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation altering degron motif	0.7427
p.V1386I	TCGA-EO-A3AU	UCEC	TCGA	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.3056
p.V1386I	DO43827	UCEC	ICGC	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.3056
p.N1921S	DO227424	EOPC	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation rewiring degron network	0.1111
p.A1904V	DO233855	GACA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation rewiring degron network	0.3056
p.S1911R	DO229038	LICA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation altering degron motif	0.6316
p.S1902T	DO28962	OV	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	1905:1913	Mutation rewiring degron network	0.25
p.E583D	DO34648	PACA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation rewiring degron network	0.0556
p.D1375N	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.1389
p.D1375N	ACH-000665	Lung Cancer	CCLE	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.1389
p.D1375N	SK-MES-1	lung	COSMIC	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.1389
p.P1377S	SIDM00282	Colorectal Carcinoma	GDSC	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.1944
p.P1377S	ACH-000998	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.1944
p.P1377S	CW-2	large intestine	COSMIC	PPGY	ITCH	1382:1385	Mutation rewiring degron network	0.1944
p.L586F	ACH-001864	Bile Duct Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation rewiring degron network	0.1389
p.Q600E	SW954	vulva	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	593:598	Mutation rewiring degron network	0.2778

Kaplan plot for DICER1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DICER1

UniProt ID: Q9UPY3

Entrez ID: 23405

Protein name: Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DICER1 in