DegronMD

Uniprot ID: Q9UPY3

Source protein: Endoribonuclease Dicer

Source gene: DICER1

Class: DEG_APCC_DBOX_1

Location: 1905:1913

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8001

ASA_SCORE: 52.1667

COIL: 0.0339

CONS_SCORE: 0.3771

DSS_SCORE: 0.4844

HELIX: 0.9684

FCONS_SCORE: 1.2463

RIG_SCORE: 0.7645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1898M	TCGA-AX-A2HD	UCEC	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	0.1389
p.R1898M	DO42608	UCEC	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.1389
p.R1910Q	TCGA-B5-A1MR	UCEC	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	0.6218
p.R1910Q	DO222798	COCA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.6218
p.R1910Q	DO50917	LICA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.6218
p.R1910Q	DO41758	UCEC	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.6218
p.S1902F	TCGA-D9-A6EC	SKCM	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	0.25
p.S1902F	DO50291	SKCM	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.25
p.R1906S	TCGA-EM-A2CT	THCA	TCGA	ARRALRSLK	DEG_APCC_DBOX_1	0.7427
p.R1906S	DO39198	THCA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.7427
p.N1921S	DO227424	EOPC	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.1111
p.A1904V	DO233855	GACA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.3056
p.S1911R	DO229038	LICA	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.6316
p.S1902T	DO28962	OV	ICGC	ARRALRSLK	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPY3	Endoribonuclease Dicer	DEG_APCC_DBOX_1	1905:1913	ARRALRSLK	APC,CDC20,FZR1	0.8001	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons