DegronMD

Uniprot ID: Q9UPY3

Source protein: Endoribonuclease Dicer

Source gene: DICER1

Class: DEG_Kelch_Keap1_1

Location: 593:598

E3 ligase: KEAP1

DEGRON score: 0.744

ASA_SCORE: 86.3167

COIL: 0.9238

CONS_SCORE: 0.2416

DSS_SCORE: 0.4298

HELIX: 0.0578

FCONS_SCORE: 0.8072

RIG_SCORE: 0.6874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D600E	TCGA-CR-7402	HNSC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.2778
p.D600E	DO15727	HNSC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.2778
p.S593L	TCGA-D8-A1JG	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7667
p.S593L	DO1256	BRCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.7667
p.S591C	TCGA-E9-A244	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.2778
p.S591C	DO5263	BRCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.2778
p.E583D	DO34648	PACA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.0556
p.L586F	ACH-001864	Bile Duct Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	0.1389
p.Q600E	SW954	vulva	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_Kelch_Keap1_1	420:425	SVDTGE	KEAP1	0.7587	More...
Q9UPY3	Endoribonuclease Dicer	DEG_Kelch_Keap1_1	593:598	SVDTGE	KEAP1	0.744	More...
Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	DEG_Kelch_Keap1_1	1362:1367	SVDTGE	KEAP1	0.8216	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons