DegronMD - Q9Y6R4(MAP3K4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1366R	TCGA-3L-AA1B	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	TCGA-B5-A3FB	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	TCGA-D3-A2JE	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	TCGA-EE-A3J7	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	TCGA-FS-A1Z0	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	TCGA-NH-A6GB	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	SIDM00543	Melanoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	ACH-000388	Lymphoma	CCLE	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	ACH-000937	Leukemia	CCLE	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	ACH-000953	Leukemia	CCLE	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	ACH-002120	Skin Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	PF-382	haematopoietic and lymphoid tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1366R	GAK	skin	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.M1074I	TCGA-A5-A0G1	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6507
p.M1074I	TCGA-BK-A6W3	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6507
p.M1074I	TCGA-CJ-4907	KIRC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6507
p.M1074I	DO19743	KIRC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6507
p.M1074I	DO50076	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6507
p.M1074I	DO42472	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6507
p.R1071Q	TCGA-A5-A0VP	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6218
p.R1071Q	DO233930	GACA	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6218
p.R1071Q	DO42600	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6218
p.R1071Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6218
p.R1071Q	ACH-001230	Leukemia	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6218
p.R1071Q	ACH-002313	Lymphoma	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6218
p.R1071Q	TK	haematopoietic and lymphoid tissue	COSMIC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6218
p.M1371V	TCGA-AA-3697	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.2222
p.G1355V	TCGA-AA-3811	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.1389
p.A1370G	TCGA-AC-A4ZE	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.25
p.T1359S	TCGA-AN-A0AK	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.25
p.D1364N	TCGA-AX-A05S	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.6932
p.R1375Q	TCGA-AX-A0J0	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.1111
p.R1375Q	TCGA-BS-A0UV	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.1111
p.R1375Q	TCGA-E6-A1LX	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.1111
p.L1368P	TCGA-AX-A2IN	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.3056
p.G1366E	TCGA-DK-AA77	BLCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7199
p.S1068R	TCGA-FI-A2D5	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation blocking phosphorylation signal	0.75
p.S1068R	DO41331	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation blocking phosphorylation signal	0.75
p.W1073L	TCGA-FI-A2D5	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.7015
p.W1073L	DO41331	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.7015
p.I1361S	TCGA-P5-A5ET	LGG	TCGA	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.3056
p.Y1367C	DO227657	COCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7087
p.I1067V	DO29980	OV	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation rewiring degron network	0.2778
p.D1369N	DO228138	PBCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.2778
p.D1369N	DO42953	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.2778
p.F1364C	DO50076	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7108
p.E1355K	DO43891	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation rewiring degron network	0.1389
p.K1080R	SIDM00985	Burkitt's Lymphoma	GDSC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation substituting flanking lysine	0.3611
p.K1080R	ACH-000245	Lymphoma	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation substituting flanking lysine	0.3611
p.K1080R	BL-41	haematopoietic and lymphoid tissue	COSMIC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation substituting flanking lysine	0.3611
p.K1072R	SIDM01770	Gastric Carcinoma	GDSC	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6126
p.K1072R	ACH-000908	Gastric Cancer	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	1069:1077	Mutation altering degron motif	0.6126
p.G1362R	GAK	skin	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1362R	PF-382	haematopoietic and lymphoid tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568
p.G1362R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	1362:1367	Mutation altering degron motif	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K4

UniProt ID: Q9Y6R4

Entrez ID: 4216

Protein name: Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K4 in