DegronMD

Uniprot ID: Q9Y6R4

Source protein: Mitogen-activated protein kinase kinase kinase 4

Source gene: MAP3K4

Class: DEG_MDM2_SWIB_1

Location: 1069:1077

E3 ligase: MDM2

DEGRON score: 0.6692

ASA_SCORE: 34.4333

COIL: 0.0133

CONS_SCORE: 0.5309

DSS_SCORE: 0.0734

HELIX: 0.9856

FCONS_SCORE: 1.2768

RIG_SCORE: 0.9273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1074I	TCGA-A5-A0G1	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	0.6507
p.M1074I	TCGA-BK-A6W3	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	0.6507
p.M1074I	TCGA-CJ-4907	KIRC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	0.6507
p.M1074I	DO19743	KIRC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6507
p.M1074I	DO50076	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6507
p.M1074I	DO42472	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6507
p.R1071Q	TCGA-A5-A0VP	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	0.6218
p.R1071Q	DO233930	GACA	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6218
p.R1071Q	DO42600	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6218
p.R1071Q	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6218
p.R1071Q	ACH-001230	Leukemia	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	0.6218
p.R1071Q	ACH-002313	Lymphoma	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	0.6218
p.R1071Q	TK	haematopoietic_and_lymphoid_tissue	COSMIC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6218
p.S1068R	TCGA-FI-A2D5	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	0.75
p.S1068R	DO41331	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.75
p.W1073L	TCGA-FI-A2D5	UCEC	TCGA	FARKWMNYV	DEG_MDM2_SWIB_1	0.7015
p.W1073L	DO41331	UCEC	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.7015
p.I1067V	DO29980	OV	ICGC	FARKWMNYV	DEG_MDM2_SWIB_1	0.2778
p.K1080R	SIDM00985	Burkitt's Lymphoma	GDSC	FARKWMNYV	DEG_MDM2_SWIB_1	0.3611
p.K1080R	ACH-000245	Lymphoma	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	0.3611
p.K1080R	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	FARKWMNYV	DEG_MDM2_SWIB_1	0.3611
p.K1072R	SIDM01770	Gastric Carcinoma	GDSC	FARKWMNYV	DEG_MDM2_SWIB_1	0.6126
p.K1072R	ACH-000908	Gastric Cancer	CCLE	FARKWMNYV	DEG_MDM2_SWIB_1	0.6126

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	DEG_MDM2_SWIB_1	1069:1077	FARKWMNYV	MDM2	0.6692	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons