DegronMD

Uniprot ID: Q9Y6R4

Source protein: Mitogen-activated protein kinase kinase kinase 4

Source gene: MAP3K4

Class: DEG_Kelch_Keap1_1

Location: 1362:1367

E3 ligase: KEAP1

DEGRON score: 0.8216

ASA_SCORE: 53.6333

COIL: 0.8097

CONS_SCORE: 0.5546

DSS_SCORE: 0.1389

HELIX: 0.0113

FCONS_SCORE: 0.8858

RIG_SCORE: 0.8533

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1366R	TCGA-3L-AA1B	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	TCGA-B5-A3FB	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	TCGA-D3-A2JE	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	TCGA-EE-A3J7	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	TCGA-FS-A1Z0	SKCM	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	TCGA-NH-A6GB	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	SIDM00543	Melanoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	ACH-000388	Lymphoma	CCLE	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	ACH-000937	Leukemia	CCLE	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	ACH-000953	Leukemia	CCLE	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	ACH-002120	Skin Cancer	CCLE	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1366R	GAK	skin	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.M1371V	TCGA-AA-3697	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.2222
p.G1355V	TCGA-AA-3811	COAD	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.1389
p.A1370G	TCGA-AC-A4ZE	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.25
p.T1359S	TCGA-AN-A0AK	BRCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.25
p.D1364N	TCGA-AX-A05S	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.6932
p.R1375Q	TCGA-AX-A0J0	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.1111
p.R1375Q	TCGA-BS-A0UV	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.1111
p.R1375Q	TCGA-E6-A1LX	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.1111
p.L1368P	TCGA-AX-A2IN	UCEC	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.3056
p.G1366E	TCGA-DK-AA77	BLCA	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.7199
p.I1361S	TCGA-P5-A5ET	LGG	TCGA	SVDTGE	DEG_Kelch_Keap1_1	0.3056
p.Y1367C	DO227657	COCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.7087
p.D1369N	DO228138	PBCA	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.2778
p.D1369N	DO42953	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.2778
p.F1364C	DO50076	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.7108
p.E1355K	DO43891	UCEC	ICGC	SVDTGE	DEG_Kelch_Keap1_1	0.1389
p.G1362R	GAK	skin	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1362R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.7568
p.G1362R	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SVDTGE	DEG_Kelch_Keap1_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_Kelch_Keap1_1	420:425	SVDTGE	KEAP1	0.7587	More...
Q9UPY3	Endoribonuclease Dicer	DEG_Kelch_Keap1_1	593:598	SVDTGE	KEAP1	0.744	More...
Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	DEG_Kelch_Keap1_1	1362:1367	SVDTGE	KEAP1	0.8216	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SVDTGE

Degron related mutations and impact score

Drug responses associated with MAP3K4 mutations

All proteins holding degron of SVDTGE