DegronMD - Q99501(GAS2L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L532F	DO52079	HNSC	ICGC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.1389
p.L536P	DO46542	OV	ICGC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.25
p.P531H	DO46542	OV	ICGC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.1111
p.N588S	SIDM01307	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	597:601	Mutation rewiring degron network	0.0833
p.A555G	SIDM01298	Esophageal Carcinoma	GDSC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.1111
p.S679F	SIDM00216	Colorectal Carcinoma	GDSC	VTPRAE	DEG_SCF_FBW7_2	671:676	Mutation rewiring degron network	0.25
p.S602C	SIDM00570	Gastric Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	597:601	Mutation rewiring degron network	0.3056
p.A550V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.25
p.A550V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.25
p.P677S	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VTPRAE	DEG_SCF_FBW7_2	671:676	Mutation rewiring degron network	0.3056
p.P677S	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	VTPRAE	DEG_SCF_FBW7_2	671:676	Mutation rewiring degron network	0.3056
p.R530W	SIDM00050	Chondrosarcoma	GDSC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.0833
p.R530W	CHSA0108	bone	COSMIC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation rewiring degron network	0.0833
p.P543A	SIDM00951	T-Lymphoblastic Leukemia	GDSC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation altering degron motif	0.6392
p.P543A	CTV-1	haematopoietic and lymphoid tissue	COSMIC	TPTGPVPDP	DEG_COP1_1	539:547	Mutation altering degron motif	0.6392

Kaplan plot for GAS2L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAS2L1

UniProt ID: Q99501

Entrez ID: 10634

Protein name: GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAS2L1 in