DegronMD

Uniprot ID: Q99501

Source protein: GAS2-like protein 1

Source gene: GAS2L1

Class: DEG_COP1_1

Location: 539:547

E3 ligase: COP1

DEGRON score: 0.9928

ASA_SCORE: 94.6556

COIL: 0.9621

CONS_SCORE: 0.299

DSS_SCORE: 0.6195

HELIX: 0.017

FCONS_SCORE: 0.8009

RIG_SCORE: 0.617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L532F	DO52079	HNSC	ICGC	TPTGPVPDP	DEG_COP1_1	0.1389
p.L536P	DO46542	OV	ICGC	TPTGPVPDP	DEG_COP1_1	0.25
p.P531H	DO46542	OV	ICGC	TPTGPVPDP	DEG_COP1_1	0.1111
p.A555G	SIDM01298	Esophageal Carcinoma	GDSC	TPTGPVPDP	DEG_COP1_1	0.1111
p.A550V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	TPTGPVPDP	DEG_COP1_1	0.25
p.A550V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	TPTGPVPDP	DEG_COP1_1	0.25
p.R530W	SIDM00050	Chondrosarcoma	GDSC	TPTGPVPDP	DEG_COP1_1	0.0833
p.R530W	CHSA0108	bone	COSMIC	TPTGPVPDP	DEG_COP1_1	0.0833
p.P543A	SIDM00951	T-Lymphoblastic Leukemia	GDSC	TPTGPVPDP	DEG_COP1_1	0.6392
p.P543A	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	TPTGPVPDP	DEG_COP1_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99501	GAS2-like protein 1	DEG_COP1_1	539:547	TPTGPVPDP	COP1	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons