DegronMD

Uniprot ID: Q99501

Source protein: GAS2-like protein 1

Source gene: GAS2L1

Class: DEG_SCF_FBW7_2

Location: 671:676

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 101.65

COIL: 0.9257

CONS_SCORE: 0.3106

DSS_SCORE: 0.6172

HELIX: 0.0398

FCONS_SCORE: 1.1259

RIG_SCORE: 0.6829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S679F	SIDM00216	Colorectal Carcinoma	GDSC	VTPRAE	DEG_SCF_FBW7_2	0.25
p.P677S	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VTPRAE	DEG_SCF_FBW7_2	0.3056
p.P677S	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPRAE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99501	GAS2-like protein 1	DEG_SCF_FBW7_2	671:676	VTPRAE	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons