DegronMD - Q9HAK2(EBF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A420V	TCGA-24-2260	OV	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2778
p.A420V	SIDM01138	Pancreatic Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2778
p.A420V	ACH-000139	Pancreatic Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2778
p.A420V	PANC-03-27	pancreas	COSMIC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2778
p.L490V	TCGA-2H-A9GH	ESCA	TCGA	NSMNGYSNVP	CBL_PTK	477:486	Mutation rewiring degron network	0.2222
p.L490V	TCGA-BH-A0AW	BRCA	TCGA	NSMNGYSNVP	CBL_PTK	477:486	Mutation rewiring degron network	0.2222
p.L490V	TCGA-VQ-A8PJ	STAD	TCGA	NSMNGYSNVP	CBL_PTK	477:486	Mutation rewiring degron network	0.2222
p.S530F	TCGA-69-A59K	LUAD	TCGA	PFSSS	DEG_SPOP_SBC_1	527:531	Mutation altering degron motif	0.7982
p.G423A	TCGA-86-8673	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.A488T	TCGA-A5-A0G1	UCEC	TCGA	NSMNGYSNVP	CBL_PTK	477:486	Mutation rewiring degron network	0.2778
p.S422N	TCGA-AP-A051	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2222
p.S422N	DO42673	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2222
p.R407S	TCGA-AP-A1DV	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.R407S	DO43186	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.Q538E	TCGA-BA-5152	HNSC	TCGA	PFSSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1389
p.Q538E	DO14393	HNSC	ICGC	PFSSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1389
p.S521N	TCGA-BR-4368	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation altering degron motif	0.7069
p.R407K	TCGA-CG-5723	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.R407K	TCGA-EB-A44O	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.R407K	DO47272	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.R407K	DO38376	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.M511T	TCGA-CM-4743	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.1667
p.M511T	DO8103	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.1667
p.P534S	TCGA-D3-A3ML	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.25
p.P534S	TCGA-IH-A3EA	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.25
p.P534S	DO37667	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.25
p.P534S	DO47413	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.25
p.P515S	TCGA-EE-A181	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.2778
p.P515S	DO37444	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.2778
p.S519F	TCGA-FR-A8YC	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation altering degron motif	0.7982
p.S519F	DO50301	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation altering degron motif	0.7982
p.M479I	TCGA-FS-A4F5	SKCM	TCGA	NSMNGYSNVP	CBL_PTK	477:486	Mutation altering degron motif	0.6507
p.M511L	TCGA-FW-A3R5	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.1667
p.P409S	TCGA-FW-A3R5	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.S483N	TCGA-N7-A4Y0	UCS	TCGA	NSMNGYSNVP	CBL_PTK	477:486	Mutation altering degron motif	0.7069
p.N408D	TCGA-W3-AA1V	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1667
p.N408D	DO51276	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1667
p.V405I	DO224600	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.V405I	DO1011	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.V405I	DO222713	BTCA	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.V405I	DO7412	CLLE	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.V405I	SIDM00789	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.V405I	ACH-000997	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.V405I	HCT-15	large intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0833
p.F416S	DO222798	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7982
p.P496Q	DO229018	LICA	ICGC	NSMNGYSNVP	CBL_PTK	477:486	Mutation rewiring degron network	0.0556
p.P425H	DO229019	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.P425H	DO42033	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.L422I	DO229041	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2222
p.P413L	DO50970	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.3056
p.A407G	DO219129	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1389
p.S512L	DO222753	MELA	ICGC	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.1944
p.G415E	DO37559	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7199
p.G415E	DO47288	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7199
p.G415E	DO37421	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7199
p.G415E	DO50288	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7199
p.G415E	DO51301	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7199
p.G413R	DO219466	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.3056
p.S514R	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.25
p.S514R	ACH-000664	Lymphoma	CCLE	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.25
p.S514R	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	517:521	Mutation rewiring degron network	0.25
p.T474A	SIDM01394	Kidney Carcinoma	GDSC	NSMNGYSNVP	CBL_PTK	477:486	Mutation rewiring degron network	0.25
p.S410N	ACH-000586	Lung Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2222
p.S410N	NCI-H1876	lung	COSMIC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.2222
p.G481R	ACH-001413	Bladder Cancer	CCLE	NSMNGYSNVP	CBL_PTK	477:486	Mutation altering degron motif	0.6457
p.S404N	ACH-001526	Bone Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0556
p.N408H	ACH-002396	Bone Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1667
p.N408H	Sarc9371	bone	COSMIC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1667
p.G421E	SW684	soft tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.25
p.G415R	SW684	soft tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7568
p.P426L	ACN	autonomic ganglia	COSMIC	ALSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EBF2

UniProt ID: Q9HAK2

Entrez ID: 64641

Protein name: Transcription factor COE2 (Early B-cell factor 2) (EBF-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EBF2 in