DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NSMNGYSNVP
Uniprot ID:
Q9HAK2
Source protein:
Transcription factor COE2
Source gene:
EBF2
Class:
CBL_PTK
Location:
477:486
E3 ligase:
CBL
DEGRON score:
0.665
ASA_SCORE:
58.22
COIL:
0.7619
CONS_SCORE:
0.324
DSS_SCORE:
0.4929
HELIX:
0.085
FCONS_SCORE:
0.9648
RIG_SCORE:
0.6457
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L490V
TCGA-2H-A9GH
ESCA
TCGA
NSMNGYSNVP
CBL_PTK
0.2222
p.L490V
TCGA-BH-A0AW
BRCA
TCGA
NSMNGYSNVP
CBL_PTK
0.2222
p.L490V
TCGA-VQ-A8PJ
STAD
TCGA
NSMNGYSNVP
CBL_PTK
0.2222
p.A488T
TCGA-A5-A0G1
UCEC
TCGA
NSMNGYSNVP
CBL_PTK
0.2778
p.M479I
TCGA-FS-A4F5
SKCM
TCGA
NSMNGYSNVP
CBL_PTK
0.6507
p.S483N
TCGA-N7-A4Y0
UCS
TCGA
NSMNGYSNVP
CBL_PTK
0.7069
p.P496Q
DO229018
LICA
ICGC
NSMNGYSNVP
CBL_PTK
0.0556
p.T474A
SIDM01394
Kidney Carcinoma
GDSC
NSMNGYSNVP
CBL_PTK
0.25
p.G481R
ACH-001413
Bladder Cancer
CCLE
NSMNGYSNVP
CBL_PTK
0.6457
Drug responses associated with EBF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSMNGYSNVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HAK2
Transcription factor COE2
CBL_PTK
477:486
NSMNGYSNVP
CBL
0.665
More...
