DegronMD - Q9NQW6(ANLN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E683K	TCGA-06-5416	GBM	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.0833
p.E683K	DO10880	GBM	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.0833
p.K298E	TCGA-43-5668	LUSC	TCGA	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.591
p.K298E	DO26608	LUSC	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.591
p.V79I	TCGA-91-6848	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.V79I	TCGA-BS-A0UF	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.V79I	DO23846	LUAD	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.V79I	DO41488	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0833
p.R667H	TCGA-A5-A0G2	UCEC	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.8244
p.R667H	DO41235	UCEC	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.8244
p.R667H	ACH-000470	Colon/Colorectal Cancer	CCLE	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.8244
p.C309Y	TCGA-A5-A0GB	UCEC	TCGA	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.C309Y	DO41434	UCEC	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.A280V	TCGA-AA-3492	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.A280V	DO8224	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.A280V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.A280V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.A280V	SIDM00487	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.A280V	ACH-000963	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.A280V	ACH-000995	Leukemia	CCLE	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.A280V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.2222
p.R11Q	TCGA-AA-3984	COAD	TCGA	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1944
p.R11Q	DO9002	COAD	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1944
p.R11Q	DO233764	GACA	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1944
p.D666Y	TCGA-AJ-A3EK	UCEC	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.6214
p.D666Y	DO41584	UCEC	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.6214
p.A267T	TCGA-AP-A0LM	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1944
p.A267T	DO43306	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1944
p.G311E	TCGA-AR-A5QN	BRCA	TCGA	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0556
p.G311E	DO44245	BRCA	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0556
p.G197S	TCGA-B0-5691	KIRC	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.G197S	DO20496	KIRC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.R410I	TCGA-B5-A1MR	UCEC	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.0833
p.R410I	DO41758	UCEC	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.0833
p.A193T	TCGA-B5-A3FC	UCEC	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1944
p.A193T	DO41871	UCEC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1944
p.L669I	TCGA-BR-A4IU	STAD	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.6063
p.L669I	DO38515	STAD	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation altering degron motif	0.6063
p.D266N	TCGA-BS-A0UV	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.D266N	TCGA-E6-A1LX	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.D266N	DO41020	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.D266N	DO42793	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.T363A	TCGA-CN-A6V3	HNSC	TCGA	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.5833
p.T363A	DO233652	GACA	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.5833
p.T363A	DO52050	HNSC	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.5833
p.D640H	TCGA-CX-7086	HNSC	TCGA	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation rewiring degron network	0.1111
p.P389T	TCGA-D3-A2JL	SKCM	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1944
p.P389T	DO47278	SKCM	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1944
p.K361R	TCGA-DF-A2KR	UCEC	TCGA	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation substituting flanking lysine	0.1944
p.K361R	DO223284	UCEC	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation substituting flanking lysine	0.1944
p.E387D	TCGA-DF-A2KU	UCEC	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.E387D	TCGA-UY-A78K	BLCA	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.E387D	DO219031	BLCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.E387D	DO223286	UCEC	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.1389
p.R376C	TCGA-DU-6392	LGG	TCGA	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.3056
p.R376C	DO22237	LGG	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.3056
p.R376C	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.3056
p.R376C	TE-9	oesophagus	COSMIC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.3056
p.R13S	TCGA-EE-A2MG	SKCM	TCGA	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.R13S	DO37421	SKCM	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.P622S	TCGA-EE-A2MR	SKCM	TCGA	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation rewiring degron network	0.25
p.P622S	DO37819	SKCM	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation rewiring degron network	0.25
p.P365Q	TCGA-EE-A3AD	SKCM	TCGA	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.P365Q	DO37707	SKCM	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.E78D	TCGA-EO-A3B0	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0556
p.E78D	DO219773	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0556
p.S192L	TCGA-EX-A8YF	CESC	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.S192L	DO49970	CESC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.P372L	TCGA-FS-A4FC	SKCM	TCGA	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.6471
p.P372L	DO37762	SKCM	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation altering degron motif	0.6471
p.S362Y	TCGA-G3-AAUZ	LIHC	TCGA	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.5556
p.S362Y	DO52293	LIHC	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.5556
p.P87L	TCGA-GC-A3YS	BLCA	TCGA	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.P87L	DO850	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.A285T	TCGA-IB-7651	PAAD	TCGA	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.0833
p.A285T	DO46657	PAAD	ICGC	ALSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.0833
p.G197D	TCGA-L5-A8NM	ESCA	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.P296S	TCGA-LL-A5YN	BRCA	TCGA	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.3056
p.P296S	DO50049	BRCA	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.3056
p.E89D	TCGA-NJ-A4YF	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.5647
p.E89D	DO218940	LUAD	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.5647
p.P402S	TCGA-PK-A5HB	ACC	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.3056
p.I400V	TCGA-W3-AA1V	SKCM	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5965
p.I400V	DO51276	SKCM	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5965
p.K94Q	DO48457	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2778
p.S621R	DO225331	BRCA	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation blocking phosphorylation signal	0.6667
p.S288Y	DO234386	ESAD	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0833
p.H384R	DO48203	ESCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.0556
p.H384R	DO48203	ESCA	ICGC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0833
p.C309W	DO223009	ESCA	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.K85I	DO228187	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation blocking ubiquitination signal	0.6944
p.A93V	DO231939	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.3056
p.I400T	DO228813	LICA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.5966
p.A306S	DO228933	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.A306S	DO229024	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.D214Y	DO228976	LICA	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.R13L	DO228986	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.R13L	DO229019	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1389
p.L82F	DO229024	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1667
p.C309F	DO229024	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.R391L	DO229026	LICA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.25
p.S624I	DO229038	LICA	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation blocking phosphorylation signal	0.75
p.E6D	DO229041	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.5647
p.R16L	DO229045	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.R16L	DO229006	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.T294A	DO231832	LINC	ICGC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation blocking phosphorylation signal	0.6944
p.G200S	DO23388	LINC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5882
p.G200S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5882
p.R615P	DO45317	LUAD	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation rewiring degron network	0.0556
p.K659T	DO24940	LUAD	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.1389
p.T404A	DO232761	PBCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation blocking phosphorylation signal	0.6944
p.T404A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation blocking phosphorylation signal	0.6944
p.T404A	ACH-000983	Leukemia	CCLE	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation blocking phosphorylation signal	0.6944
p.T404A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation blocking phosphorylation signal	0.6944
p.E628K	DO229479	SKCA	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation altering degron motif	0.7022
p.R410S	DO229192	THCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.0833
p.S289R	SIDM00074	Burkitt's Lymphoma	GDSC	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation blocking phosphorylation signal	0.5556
p.S289R	ACH-000402	Lymphoma	CCLE	VKSTT	DEG_SPOP_SBC_1	297:301	Mutation blocking phosphorylation signal	0.5556
p.T404S	SIDM01265	Plasma Cell Myeloma	GDSC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation blocking phosphorylation signal	0.6944
p.T404S	ACH-000763	Myeloma	CCLE	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation blocking phosphorylation signal	0.6944
p.T404S	MM1S	haematopoietic and lymphoid tissue	COSMIC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation blocking phosphorylation signal	0.6944
p.T368R	SIDM00845	Burkitt's Lymphoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.7222
p.T5M	SIDM00120	Prostate Carcinoma	GDSC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.7423
p.T5M	ACH-000979	Prostate Cancer	CCLE	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.7423
p.T5M	DU-145	prostate	COSMIC	MDPFTE	LIG_APCC_ABBA_1	1:6	Mutation altering degron motif	0.7423
p.D360A	SIDM00928	Breast Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.D360A	ACH-000857	Breast Cancer	CCLE	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.D360A	CAL-85-1	breast	COSMIC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.0556
p.D635A	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation rewiring degron network	0.25
p.D635A	ACH-000858	Lung Cancer	CCLE	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation rewiring degron network	0.25
p.D635A	KNS-62	lung	COSMIC	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation rewiring degron network	0.25
p.T397I	SIDM00543	Melanoma	GDSC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.8189
p.T397I	ACH-002120	Skin Cancer	CCLE	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.8189
p.T397I	GAK	skin	COSMIC	PHRTPIIT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.8189
p.C96Y	SIDM00901	Endometrial Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.C96Y	ACH-000940	Endometrial/Uterine Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.C96Y	AN3-CA	endometrium	COSMIC	VESTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.S192W	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRGRLANLA	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.S362P	SIDM01753	Gastric Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation blocking phosphorylation signal	0.5556
p.P365A	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.1944
p.S642R	ACH-000941	Endometrial/Uterine Cancer	CCLE	LVSTPRLE	DEG_SCF_FBW7_2	625:632	Mutation blocking phosphorylation signal	0.5
p.G369R	ACH-001786	Colon/Colorectal Cancer	CCLE	IKPFLE	LIG_APCC_ABBA_1	370:375	Mutation rewiring degron network	0.3056
p.M683V	RERF-LC-Sq1	lung	COSMIC	DRDLLYSID	DEG_APCC_DBOX_1	666:674	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANLN

UniProt ID: Q9NQW6

Entrez ID: 54443

Protein name: Anillin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANLN in