DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: DEG_APCC_DBOX_1

Location: 666:674

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9849

ASA_SCORE: 92.7778

COIL: 0.6854

CONS_SCORE: 0.4946

DSS_SCORE: 0.4013

HELIX: 0.2629

FCONS_SCORE: 1.0494

RIG_SCORE: 0.8062

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E683K	TCGA-06-5416	GBM	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	0.0833
p.E683K	DO10880	GBM	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	0.0833
p.R667H	TCGA-A5-A0G2	UCEC	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	0.8244
p.R667H	DO41235	UCEC	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	0.8244
p.R667H	ACH-000470	Colon/Colorectal Cancer	CCLE	DRDLLYSID	DEG_APCC_DBOX_1	0.8244
p.D666Y	TCGA-AJ-A3EK	UCEC	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	0.6214
p.D666Y	DO41584	UCEC	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	0.6214
p.L669I	TCGA-BR-A4IU	STAD	TCGA	DRDLLYSID	DEG_APCC_DBOX_1	0.6063
p.L669I	DO38515	STAD	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	0.6063
p.K659T	DO24940	LUAD	ICGC	DRDLLYSID	DEG_APCC_DBOX_1	0.1389
p.M683V	RERF-LC-Sq1	lung	COSMIC	DRDLLYSID	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	DEG_APCC_DBOX_1	666:674	DRDLLYSID	APC,CDC20,FZR1	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons