DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: DEG_SPOP_SBC_1

Location: 297:301

E3 ligase: SPOP

DEGRON score: 0.991

ASA_SCORE: 102.6

COIL: 0.9302

CONS_SCORE: 0.4721

DSS_SCORE: 0.4422

HELIX: 0.0244

FCONS_SCORE: 1.0651

RIG_SCORE: 0.6591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K298E	TCGA-43-5668	LUSC	TCGA	VKSTT	DEG_SPOP_SBC_1	0.591
p.K298E	DO26608	LUSC	ICGC	VKSTT	DEG_SPOP_SBC_1	0.591
p.C309Y	TCGA-A5-A0GB	UCEC	TCGA	VKSTT	DEG_SPOP_SBC_1	0.1111
p.C309Y	DO41434	UCEC	ICGC	VKSTT	DEG_SPOP_SBC_1	0.1111
p.G311E	TCGA-AR-A5QN	BRCA	TCGA	VKSTT	DEG_SPOP_SBC_1	0.0556
p.G311E	DO44245	BRCA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.0556
p.P296S	TCGA-LL-A5YN	BRCA	TCGA	VKSTT	DEG_SPOP_SBC_1	0.3056
p.P296S	DO50049	BRCA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.3056
p.S288Y	DO234386	ESAD	ICGC	VKSTT	DEG_SPOP_SBC_1	0.0833
p.C309W	DO223009	ESCA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.1111
p.A306S	DO228933	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.1944
p.A306S	DO229024	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.1944
p.C309F	DO229024	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.1111
p.T294A	DO231832	LINC	ICGC	VKSTT	DEG_SPOP_SBC_1	0.6944
p.S289R	SIDM00074	Burkitt's Lymphoma	GDSC	VKSTT	DEG_SPOP_SBC_1	0.5556
p.S289R	ACH-000402	Lymphoma	CCLE	VKSTT	DEG_SPOP_SBC_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40692	DNA mismatch repair protein Mlh1	DEG_SPOP_SBC_1	360:364	VKSTT	SPOP	0.9571	More...
Q8NHM5	Lysine-specific demethylase 2B	DEG_SPOP_SBC_1	481:485	VKSTT	SPOP	0.9987	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	297:301	VKSTT	SPOP	0.991	More...
Q9Y265	RuvB-like 1	DEG_SPOP_SBC_1	6:10	VKSTT	SPOP	0.8534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons