DegronMD

Uniprot ID: P40692

Source protein: DNA mismatch repair protein Mlh1

Source gene: MLH1

Class: DEG_SPOP_SBC_1

Location: 360:364

E3 ligase: SPOP

DEGRON score: 0.9571

ASA_SCORE: 90.98

COIL: 0.8502

CONS_SCORE: 0.252

DSS_SCORE: 0.5575

HELIX: 0.0546

FCONS_SCORE: 0.8097

RIG_SCORE: 0.7088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T364A	TCGA-EO-A3AY	UCEC	TCGA	VKSTT	DEG_SPOP_SBC_1	0.7139
p.S368L	TCGA-FW-A3R5	SKCM	TCGA	VKSTT	DEG_SPOP_SBC_1	0.2222
p.M360I	DO229031	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.7618
p.G373A	SIDM01123	Prostate Carcinoma	GDSC	VKSTT	DEG_SPOP_SBC_1	0.0833
p.G373A	ACH-000177	Prostate Cancer	CCLE	VKSTT	DEG_SPOP_SBC_1	0.0833
p.G373A	NCI-H660	prostate	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.0833
p.P362R	ES8	bone	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.7512
p.P362R	HT-1376	urinary_tract	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.7512
p.S374R	MRK-nu-1	breast	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.0556
p.E362A	786-0	kidney	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40692	DNA mismatch repair protein Mlh1	DEG_SPOP_SBC_1	360:364	VKSTT	SPOP	0.9571	More...
Q8NHM5	Lysine-specific demethylase 2B	DEG_SPOP_SBC_1	481:485	VKSTT	SPOP	0.9987	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	297:301	VKSTT	SPOP	0.991	More...
Q9Y265	RuvB-like 1	DEG_SPOP_SBC_1	6:10	VKSTT	SPOP	0.8534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons