DegronMD - Q8NHM5(KDM2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L831F	TCGA-78-7156	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.2778
p.L831F	DO23720	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.2778
p.P494L	TCGA-90-A4ED	LUSC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7582
p.P494L	DO45482	LUSC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7582
p.S820L	TCGA-AG-A002	READ	TCGA	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.S820L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.S820L	ACH-002253	Lymphoma	CCLE	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.S820L	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.A818V	TCGA-AX-A06F	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.1389
p.A818V	DO41752	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.1389
p.R471K	TCGA-AX-A0J1	UCEC	TCGA	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0556
p.R471K	DO41199	UCEC	ICGC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0556
p.K492N	TCGA-B5-A0JY	UCEC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.5806
p.K492N	DO43041	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.5806
p.E501D	TCGA-CC-A8HT	LIHC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.2222
p.E501D	DO52187	LIHC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.2222
p.Q822E	TCGA-DK-AA6L	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.25
p.Q822E	DO219002	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.25
p.S474F	TCGA-H7-A76A	HNSC	TCGA	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation blocking phosphorylation signal	0.5833
p.S474F	DO52088	HNSC	ICGC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation blocking phosphorylation signal	0.5833
p.L821I	TCGA-VS-A8EK	CESC	TCGA	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.2222
p.L821I	DO51623	CESC	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.2222
p.G498D	DO8400	COAD	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.3056
p.R815S	DO228978	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.0556
p.R815S	DO229031	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.0556
p.P502T	DO228985	LICA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.1944
p.A496E	DO229026	LICA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7701
p.S483F	DO220886	MELA	ICGC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.7982
p.T495P	DO49184	PACA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7031
p.R815H	DO232675	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.0556
p.A818S	DO229264	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.1389
p.P503H	DO219774	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6111
p.A496V	DO41752	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.6936
p.S504Y	DO41680	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.1389
p.R499H	DO43891	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.2778
p.R834S	ACH-001610	Brain Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation rewiring degron network	0.1944
p.T500P	ACH-002282	Neuroblastoma	CCLE	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.T500P	ACH-002340	Neuroblastoma	CCLE	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.T500P	NB17	autonomic ganglia	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.T500P	NBsusSR	autonomic ganglia	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.S480P	GP5d	large intestine	COSMIC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation blocking phosphorylation signal	0.75
p.V490M	SW48	large intestine	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.3056
p.V490M	SW48	large intestine	COSMIC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1944
p.G488D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.25
p.G488D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.25
p.R504Q	RL95-2	endometrium	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation rewiring degron network	0.1389
p.L496F	NCI-H1770	lung	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.6981

Kaplan plot for KDM2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM2B

UniProt ID: Q8NHM5

Entrez ID: 84678

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM2B in