DegronMD - Q8NHM5(KDM2B)

FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no ac... View more >>

GO - Biological processes (BP): chromatin organization [GO:0006325]; embryonic camera-type eye morphogenesis [GO:0048596]; forebrain development [GO:0030900]; fourth ventricle development [GO:0021592]; hindbrain development [GO:0030902]; histone H2A monoubiquitination [GO:0035518]; histone H3-K36 demethylation [GO:0070544]; initia... View more >>

GO - Molecular function (MF): DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3-di/monomethyl-lysine-36 demethylase activity [GO:0140680]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; rRNA binding [... View more >>

GO - Cellular component (CC): chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PKTPTGS	DEG_SCF_FBW7_1	FBXW7	Lysine-specific demethylase 2B	491:497	More..
VKSTT	DEG_SPOP_SBC_1	SPOP	Lysine-specific demethylase 2B	481:485	More..
PGSSS	DEG_SPOP_SBC_1	SPOP	Lysine-specific demethylase 2B	825:829	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S483F	DO220886	MELA	ICGC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.7982
p.A496E	DO229026	LICA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7701
p.P494L	TCGA-90-A4ED	LUSC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7582
p.P494L	DO45482	LUSC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7582
p.S480P	GP5d	large intestine	COSMIC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation blocking phosphorylation signal	0.75
p.T495P	DO49184	PACA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.7031
p.L496F	NCI-H1770	lung	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.6981
p.T500P	ACH-002282	Neuroblastoma	CCLE	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.T500P	ACH-002340	Neuroblastoma	CCLE	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.T500P	NB17	autonomic ganglia	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.T500P	NBsusSR	autonomic ganglia	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6944
p.A496V	DO41752	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.6936
p.S820L	TCGA-AG-A002	READ	TCGA	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.S820L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.S820L	ACH-002253	Lymphoma	CCLE	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.S820L	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	825:829	Mutation blocking phosphorylation signal	0.6389
p.P503H	DO219774	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation blocking phosphorylation signal	0.6111
p.S474F	TCGA-H7-A76A	HNSC	TCGA	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation blocking phosphorylation signal	0.5833
p.S474F	DO52088	HNSC	ICGC	VKSTT	DEG_SPOP_SBC_1	481:485	Mutation blocking phosphorylation signal	0.5833
p.K492N	TCGA-B5-A0JY	UCEC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	491:497	Mutation altering degron motif	0.5806

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Kaplan plot for KDM2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM2B

UniProt ID: Q8NHM5

Entrez ID: 84678

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM2B in