DegronMD

Uniprot ID: Q8NHM5

Source protein: Lysine-specific demethylase 2B

Source gene: KDM2B

Class: DEG_SCF_FBW7_1

Location: 491:497

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 69.6286

COIL: 0.8693

CONS_SCORE: 0.2907

DSS_SCORE: 0.478

HELIX: 0.044

FCONS_SCORE: 0.9624

RIG_SCORE: 0.6556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P494L	TCGA-90-A4ED	LUSC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	0.7582
p.P494L	DO45482	LUSC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.7582
p.K492N	TCGA-B5-A0JY	UCEC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	0.5806
p.K492N	DO43041	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.5806
p.E501D	TCGA-CC-A8HT	LIHC	TCGA	PKTPTGS	DEG_SCF_FBW7_1	0.2222
p.E501D	DO52187	LIHC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.2222
p.G498D	DO8400	COAD	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.3056
p.P502T	DO228985	LICA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.1944
p.A496E	DO229026	LICA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.7701
p.T495P	DO49184	PACA	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.7031
p.P503H	DO219774	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.6111
p.A496V	DO41752	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.6936
p.S504Y	DO41680	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.1389
p.R499H	DO43891	UCEC	ICGC	PKTPTGS	DEG_SCF_FBW7_1	0.2778
p.T500P	ACH-002282	Neuroblastoma	CCLE	PKTPTGS	DEG_SCF_FBW7_1	0.6944
p.T500P	ACH-002340	Neuroblastoma	CCLE	PKTPTGS	DEG_SCF_FBW7_1	0.6944
p.T500P	NB17	autonomic_ganglia	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	0.6944
p.T500P	NBsusSR	autonomic_ganglia	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	0.6944
p.V490M	SW48	large_intestine	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	0.3056
p.G488D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	0.25
p.R504Q	RL95-2	endometrium	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	0.1389
p.L496F	NCI-H1770	lung	COSMIC	PKTPTGS	DEG_SCF_FBW7_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHM5	Lysine-specific demethylase 2B	DEG_SCF_FBW7_1	491:497	PKTPTGS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons