DegronMD

Uniprot ID: Q8NHM5

Source protein: Lysine-specific demethylase 2B

Source gene: KDM2B

Class: DEG_SPOP_SBC_1

Location: 481:485

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 78.94

COIL: 0.7002

CONS_SCORE: 0.3006

DSS_SCORE: 0.4958

HELIX: 0.2152

FCONS_SCORE: 1.0082

RIG_SCORE: 0.7242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R471K	TCGA-AX-A0J1	UCEC	TCGA	VKSTT	DEG_SPOP_SBC_1	0.0556
p.R471K	DO41199	UCEC	ICGC	VKSTT	DEG_SPOP_SBC_1	0.0556
p.S474F	TCGA-H7-A76A	HNSC	TCGA	VKSTT	DEG_SPOP_SBC_1	0.5833
p.S474F	DO52088	HNSC	ICGC	VKSTT	DEG_SPOP_SBC_1	0.5833
p.S483F	DO220886	MELA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.7982
p.S480P	GP5d	large_intestine	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.75
p.V490M	SW48	large_intestine	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.1944
p.G488D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40692	DNA mismatch repair protein Mlh1	DEG_SPOP_SBC_1	360:364	VKSTT	SPOP	0.9571	More...
Q8NHM5	Lysine-specific demethylase 2B	DEG_SPOP_SBC_1	481:485	VKSTT	SPOP	0.9987	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	297:301	VKSTT	SPOP	0.991	More...
Q9Y265	RuvB-like 1	DEG_SPOP_SBC_1	6:10	VKSTT	SPOP	0.8534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons