DegronMD

Uniprot ID: Q9Y265

Source protein: RuvB-like 1

Source gene: RUVBL1

Class: DEG_SPOP_SBC_1

Location: 6:10

E3 ligase: SPOP

DEGRON score: 0.8534

ASA_SCORE: 89.92

COIL: 0.736

CONS_SCORE: 0.5552

DSS_SCORE: 0.6441

HELIX: 0.1178

FCONS_SCORE: 0.8382

RIG_SCORE: 0.7543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R14H	TCGA-AP-A1DV	UCEC	TCGA	VKSTT	DEG_SPOP_SBC_1	0.2222
p.R14H	DO43186	UCEC	ICGC	VKSTT	DEG_SPOP_SBC_1	0.2222
p.E4D	TCGA-BT-A3PJ	BLCA	TCGA	VKSTT	DEG_SPOP_SBC_1	0.2778
p.E4D	DO44097	BLCA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.2778
p.A16T	TCGA-VQ-A8P2	STAD	TCGA	VKSTT	DEG_SPOP_SBC_1	0.1667
p.A16T	DO51761	STAD	ICGC	VKSTT	DEG_SPOP_SBC_1	0.1667
p.E4Q	TCGA-XF-A8HE	BLCA	TCGA	VKSTT	DEG_SPOP_SBC_1	0.2778
p.E4Q	DO49797	BLCA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.2778
p.E4Q	DO223157	ESCA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.2778
p.R14S	DO229019	LICA	ICGC	VKSTT	DEG_SPOP_SBC_1	0.2222
p.I15M	SIDM00381	Cervical Carcinoma	GDSC	VKSTT	DEG_SPOP_SBC_1	0.1944
p.I15M	ACH-002020	Cervical Cancer	CCLE	VKSTT	DEG_SPOP_SBC_1	0.1944
p.I15M	SKG-IIIa	cervix	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.1944
p.A18D	ACH-000999	Colon/Colorectal Cancer	CCLE	VKSTT	DEG_SPOP_SBC_1	0.1111
p.A18D	SNU-1040	large_intestine	COSMIC	VKSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40692	DNA mismatch repair protein Mlh1	DEG_SPOP_SBC_1	360:364	VKSTT	SPOP	0.9571	More...
Q8NHM5	Lysine-specific demethylase 2B	DEG_SPOP_SBC_1	481:485	VKSTT	SPOP	0.9987	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	297:301	VKSTT	SPOP	0.991	More...
Q9Y265	RuvB-like 1	DEG_SPOP_SBC_1	6:10	VKSTT	SPOP	0.8534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons