DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: DEG_SCF_FBW7_1

Location: 394:401

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 103.875

COIL: 0.9519

CONS_SCORE: 0.4511

DSS_SCORE: 0.7333

HELIX: 0.0181

FCONS_SCORE: 1.06

RIG_SCORE: 0.683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R410I	TCGA-B5-A1MR	UCEC	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	0.0833
p.R410I	DO41758	UCEC	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.0833
p.P389T	TCGA-D3-A2JL	SKCM	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	0.1944
p.P389T	DO47278	SKCM	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.1944
p.E387D	TCGA-DF-A2KU	UCEC	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	0.1389
p.E387D	TCGA-UY-A78K	BLCA	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	0.1389
p.E387D	DO219031	BLCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.1389
p.E387D	DO223286	UCEC	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.1389
p.P402S	TCGA-PK-A5HB	ACC	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	0.3056
p.I400V	TCGA-W3-AA1V	SKCM	TCGA	PHRTPIIT	DEG_SCF_FBW7_1	0.5965
p.I400V	DO51276	SKCM	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.5965
p.H384R	DO48203	ESCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.0556
p.I400T	DO228813	LICA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.5966
p.R391L	DO229026	LICA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.25
p.T404A	DO232761	PBCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.6944
p.T404A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PHRTPIIT	DEG_SCF_FBW7_1	0.6944
p.T404A	ACH-000983	Leukemia	CCLE	PHRTPIIT	DEG_SCF_FBW7_1	0.6944
p.T404A	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PHRTPIIT	DEG_SCF_FBW7_1	0.6944
p.R410S	DO229192	THCA	ICGC	PHRTPIIT	DEG_SCF_FBW7_1	0.0833
p.T404S	SIDM01265	Plasma Cell Myeloma	GDSC	PHRTPIIT	DEG_SCF_FBW7_1	0.6944
p.T404S	ACH-000763	Myeloma	CCLE	PHRTPIIT	DEG_SCF_FBW7_1	0.6944
p.T404S	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	PHRTPIIT	DEG_SCF_FBW7_1	0.6944
p.T397I	SIDM00543	Melanoma	GDSC	PHRTPIIT	DEG_SCF_FBW7_1	0.8189
p.T397I	ACH-002120	Skin Cancer	CCLE	PHRTPIIT	DEG_SCF_FBW7_1	0.8189
p.T397I	GAK	skin	COSMIC	PHRTPIIT	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	DEG_SCF_FBW7_1	394:401	PHRTPIIT	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons