DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: DEG_APCC_DBOX_1

Location: 198:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9664

ASA_SCORE: 84.7

COIL: 0.5071

CONS_SCORE: 0.5032

DSS_SCORE: 0.3312

HELIX: 0.4656

FCONS_SCORE: 1.0901

RIG_SCORE: 0.7424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G197S	TCGA-B0-5691	KIRC	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	0.3056
p.G197S	DO20496	KIRC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	0.3056
p.A193T	TCGA-B5-A3FC	UCEC	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	0.1944
p.A193T	DO41871	UCEC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	0.1944
p.S192L	TCGA-EX-A8YF	CESC	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	0.1667
p.S192L	DO49970	CESC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	0.1667
p.G197D	TCGA-L5-A8NM	ESCA	TCGA	RRGRLANLA	DEG_APCC_DBOX_1	0.3056
p.D214Y	DO228976	LICA	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	0.1111
p.G200S	DO23388	LINC	ICGC	RRGRLANLA	DEG_APCC_DBOX_1	0.5882
p.G200S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	RRGRLANLA	DEG_APCC_DBOX_1	0.5882
p.S192W	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRGRLANLA	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	DEG_APCC_DBOX_1	198:206	RRGRLANLA	APC,CDC20,FZR1	0.9664	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons