DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: LIG_APCC_ABBA_1

Location: 370:375

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9596

ASA_SCORE: 86.3833

COIL: 0.5382

CONS_SCORE: 0.4609

DSS_SCORE: 0.6436

HELIX: 0.4085

FCONS_SCORE: 1.0732

RIG_SCORE: 0.7531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T363A	TCGA-CN-A6V3	HNSC	TCGA	IKPFLE	LIG_APCC_ABBA_1	0.5833
p.T363A	DO233652	GACA	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.5833
p.T363A	DO52050	HNSC	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.5833
p.K361R	TCGA-DF-A2KR	UCEC	TCGA	IKPFLE	LIG_APCC_ABBA_1	0.1944
p.K361R	DO223284	UCEC	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.1944
p.R376C	TCGA-DU-6392	LGG	TCGA	IKPFLE	LIG_APCC_ABBA_1	0.3056
p.R376C	DO22237	LGG	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.3056
p.R376C	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	0.3056
p.R376C	TE-9	oesophagus	COSMIC	IKPFLE	LIG_APCC_ABBA_1	0.3056
p.P365Q	TCGA-EE-A3AD	SKCM	TCGA	IKPFLE	LIG_APCC_ABBA_1	0.1944
p.P365Q	DO37707	SKCM	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.1944
p.P372L	TCGA-FS-A4FC	SKCM	TCGA	IKPFLE	LIG_APCC_ABBA_1	0.6471
p.P372L	DO37762	SKCM	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.6471
p.S362Y	TCGA-G3-AAUZ	LIHC	TCGA	IKPFLE	LIG_APCC_ABBA_1	0.5556
p.S362Y	DO52293	LIHC	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.5556
p.H384R	DO48203	ESCA	ICGC	IKPFLE	LIG_APCC_ABBA_1	0.0833
p.T368R	SIDM00845	Burkitt's Lymphoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	0.7222
p.D360A	SIDM00928	Breast Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	0.0556
p.D360A	ACH-000857	Breast Cancer	CCLE	IKPFLE	LIG_APCC_ABBA_1	0.0556
p.D360A	CAL-85-1	breast	COSMIC	IKPFLE	LIG_APCC_ABBA_1	0.0556
p.S362P	SIDM01753	Gastric Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	0.5556
p.P365A	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	IKPFLE	LIG_APCC_ABBA_1	0.1944
p.G369R	ACH-001786	Colon/Colorectal Cancer	CCLE	IKPFLE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	LIG_APCC_ABBA_1	370:375	IKPFLE	APC,CDC20,FZR1	0.9596	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons