DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7948

ASA_SCORE: 78.0667

COIL: 0.5007

CONS_SCORE: 0.5929

DSS_SCORE: 0.8927

HELIX: 0.4958

FCONS_SCORE: 1.0645

RIG_SCORE: 0.7692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11Q	TCGA-AA-3984	COAD	TCGA	MDPFTE	LIG_APCC_ABBA_1	0.1944
p.R11Q	DO9002	COAD	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.1944
p.R11Q	DO233764	GACA	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.1944
p.R13S	TCGA-EE-A2MG	SKCM	TCGA	MDPFTE	LIG_APCC_ABBA_1	0.1389
p.R13S	DO37421	SKCM	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.1389
p.R13L	DO228986	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.1389
p.R13L	DO229019	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.1389
p.E6D	DO229041	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.5647
p.R16L	DO229045	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.0556
p.R16L	DO229006	LICA	ICGC	MDPFTE	LIG_APCC_ABBA_1	0.0556
p.T5M	SIDM00120	Prostate Carcinoma	GDSC	MDPFTE	LIG_APCC_ABBA_1	0.7423
p.T5M	ACH-000979	Prostate Cancer	CCLE	MDPFTE	LIG_APCC_ABBA_1	0.7423
p.T5M	DU-145	prostate	COSMIC	MDPFTE	LIG_APCC_ABBA_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	LIG_APCC_ABBA_1	1:6	MDPFTE	APC,CDC20,FZR1	0.7948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons