DegronMD

Uniprot ID: Q9NQW6

Source protein: Anillin

Source gene: ANLN

Class: DEG_SCF_FBW7_2

Location: 625:632

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 83.1125

COIL: 0.7764

CONS_SCORE: 0.4258

DSS_SCORE: 0.524

HELIX: 0.1565

FCONS_SCORE: 1.0137

RIG_SCORE: 0.7231

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D640H	TCGA-CX-7086	HNSC	TCGA	LVSTPRLE	DEG_SCF_FBW7_2	0.1111
p.P622S	TCGA-EE-A2MR	SKCM	TCGA	LVSTPRLE	DEG_SCF_FBW7_2	0.25
p.P622S	DO37819	SKCM	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	0.25
p.S621R	DO225331	BRCA	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	0.6667
p.S624I	DO229038	LICA	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	0.75
p.R615P	DO45317	LUAD	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	0.0556
p.E628K	DO229479	SKCA	ICGC	LVSTPRLE	DEG_SCF_FBW7_2	0.7022
p.D635A	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	LVSTPRLE	DEG_SCF_FBW7_2	0.25
p.D635A	ACH-000858	Lung Cancer	CCLE	LVSTPRLE	DEG_SCF_FBW7_2	0.25
p.D635A	KNS-62	lung	COSMIC	LVSTPRLE	DEG_SCF_FBW7_2	0.25
p.S642R	ACH-000941	Endometrial/Uterine Cancer	CCLE	LVSTPRLE	DEG_SCF_FBW7_2	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	DEG_SCF_FBW7_2	625:632	LVSTPRLE	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons