DegronMD

Uniprot ID: P04049

Source protein: RAF proto-oncogene serine/threonine-protein kinase

Source gene: RAF1

Class: DEG_SPOP_SBC_1

Location: 292:296

E3 ligase: SPOP

DEGRON score: 0.9009

ASA_SCORE: 69.72

COIL: 0.8776

CONS_SCORE: 0.3592

DSS_SCORE: 0.667

HELIX: 0.1004

FCONS_SCORE: 0.9269

RIG_SCORE: 0.5205

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T303A	TCGA-FD-A6TC	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	0.5833
p.E286K	TCGA-FI-A2D0	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	0.1667
p.G297R	SIDM00856	Other Solid Cancers	GDSC	ALSSS	DEG_SPOP_SBC_1	0.3056
p.G297R	G-401	soft_tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	0.3056

Drug responses associated with RAF1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00918	OV\|ovary	p.A42V (No)	GDSC	RAF_9304	30.1741
SIDM00918	OV\|ovary	p.A42T (No)	GDSC	RAF_9304	30.1741
SIDM00839	COREAD\|large_intestine	p.G370delG (No)	GDSC	RAF_9304	3.669
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.E343G (No)	GDSC	RAF_9304	1.7192
SIDM00179	SKCM\|melanoma	p.S257L (No)	GDSC	RAF_9304	16.4307
SIDM00818	KIRC\|kidney	p.C588Y (No)	GDSC	RAF_9304	19.6306
SIDM01007	ALL\|lymphoblastic_leukemia	p.V128A (No)	GDSC	RAF_9304	5.3675
SIDM00974	SKCM\|melanoma	p.K439N (No)	GDSC	RAF_9304	0.1738
SIDM00856	UNCLASSIFIED\|kidney	p.G297R (Yes)	GDSC	RAF_9304	5.742
SIDM01051	UNCLASSIFIED\|ovary	p.V403A (No)	GDSC	RAF_9304	6.4419
SIDM00677	COREAD\|large_intestine	p.E478K (No)	GDSC	RAF_9304	2.2841
SIDM00312	MM\|myeloma	p.K171T (No)	GDSC	RAF_9304	11.319
SIDM01088	UNCLASSIFIED\|endometrium	p.R73* (No)	GDSC	RAF_9304	8.2806
SIDM00498	COREAD\|large_intestine	p.I330V (No)	GDSC	RAF_9304	6.2087
SIDM00625	UNCLASSIFIED\|uterus	p.G24S (No)	GDSC	RAF_9304	10.9218
SIDM00602	STAD\|stomach	p.R495H (No)	GDSC	RAF_9304	24.4059
SIDM00870	BRCA\|breast	p.D186V (No)	GDSC	RAF_9304	44.4482
SIDM00638	CESC\|cervix	p.Y574C (No)	GDSC	RAF_9304	10.6309
SIDM00140	SKCM\|melanoma	p.S352F (No)	GDSC	RAF_9304	11.6528
SIDM00243	UNCLASSIFIED\|testis	p.Q127K (No)	GDSC	RAF_9304	16.6246
SIDM00933	BRCA\|breast	p.A629S (No)	GDSC	RAF_9304	9.7358
SIDM00839	COREAD\|large_intestine	p.V98A (No)	GDSC	RAF_9304	3.669
SIDM00574	LGG\|glioma	p.S259F (No)	GDSC	RAF_9304	18.7017
SIDM00695	SKCM\|melanoma	p.A389P (No)	GDSC	RAF_9304	0.7017
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V226I (No)	GDSC	RAF_9304	6.8975
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P207S (No)	GDSC	RAF_9304	254.0772
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.Q335H (No)	GDSC	RAF_9304	4.9226
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F146I (No)	GDSC	RAF_9304	11.372
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.R143Q (No)	GDSC	RAF_9304	11.1476
SIDM00118	COREAD\|large_intestine	p.S257L (No)	GDSC	RAF_9304	2.9916
SIDM00860	HNSC\|head_and_neck	p.P614L (No)	GDSC	RAF_9304	6.8874

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14681	Etoposide-induced protein 2.4 homolog	DEG_SPOP_SBC_1	314:318	ALSSS	SPOP	0.7903	More...
P04049	RAF proto-oncogene serine/threonine-protein kinase	DEG_SPOP_SBC_1	292:296	ALSSS	SPOP	0.9009	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	161:165	ALSSS	SPOP	0.9989	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	123:127	ALSSS	SPOP	0.9284	More...
P48681	Nestin	DEG_SPOP_SBC_1	1448:1452	ALSSS	SPOP	0.968	More...
P53999	Activated RNA polymerase II transcriptional coactivator p15	DEG_SPOP_SBC_1	48:52	ALSSS	SPOP	0.9949	More...
Q01804	OTU domain-containing protein 4	DEG_SPOP_SBC_1	472:476	ALSSS	SPOP	0.9961	More...
Q06587	E3 ubiquitin-protein ligase RING1	DEG_SPOP_SBC_1	136:140	ALSSS	SPOP	0.9879	More...
Q13342	Nuclear body protein SP140	DEG_SPOP_SBC_1	181:185	ALSSS	SPOP	0.969	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1717:1721	ALSSS	SPOP	0.9305	More...
Q16531	DNA damage-binding protein 1	DEG_SPOP_SBC_1	760:764	ALSSS	SPOP	0.9918	More...
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	DEG_SPOP_SBC_1	1260:1264	ALSSS	SPOP	0.7764	More...
Q53ET0	CREB-regulated transcription coactivator 2	DEG_SPOP_SBC_1	396:400	ALSSS	SPOP	0.9946	More...
Q56P03	E2F-associated phosphoprotein	DEG_SPOP_SBC_1	22:26	ALSSS	SPOP	0.96	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	1139:1143	ALSSS	SPOP	0.7552	More...
Q5SXM2	snRNA-activating protein complex subunit 4	DEG_SPOP_SBC_1	1129:1133	ALSSS	SPOP	0.8944	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	717:721	ALSSS	SPOP	0.9122	More...
Q68D10	Protein SPT2 homolog	DEG_SPOP_SBC_1	276:280	ALSSS	SPOP	0.6856	More...
Q6DN90	IQ motif and SEC7 domain-containing protein 1	DEG_SPOP_SBC_1	921:925	ALSSS	SPOP	0.9622	More...
Q6EMK4	Vasorin	DEG_SPOP_SBC_1	370:374	ALSSS	SPOP	0.8789	More...
Q6UUV9	CREB-regulated transcription coactivator 1	DEG_SPOP_SBC_1	271:275	ALSSS	SPOP	0.9811	More...
Q70SY1	Cyclic AMP-responsive element-binding protein 3-like protein 2	DEG_SPOP_SBC_1	245:249	ALSSS	SPOP	0.9922	More...
Q7Z739	YTH domain-containing family protein 3	DEG_SPOP_SBC_1	211:215	ALSSS	SPOP	0.9258	More...
Q86X51	EZH inhibitory protein	DEG_SPOP_SBC_1	59:63	ALSSS	SPOP	0.8892	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	486:490	ALSSS	SPOP	0.9813	More...
Q8NEJ9	Neuroguidin	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.9753	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	803:807	ALSSS	SPOP	0.8649	More...
Q8TF30	WASP homolog-associated protein with actin, membranes and microtubules	DEG_SPOP_SBC_1	661:665	ALSSS	SPOP	0.9388	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1730:1734	ALSSS	SPOP	0.9832	More...
Q99501	GAS2-like protein 1	DEG_SPOP_SBC_1	597:601	ALSSS	SPOP	0.9987	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	2049:2053	ALSSS	SPOP	0.9596	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	414:418	ALSSS	SPOP	0.9785	More...
Q9NQW6	Anillin	DEG_SPOP_SBC_1	272:276	ALSSS	SPOP	0.9996	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	909:913	ALSSS	SPOP	0.9517	More...
Q9UFP1	Golgi-associated kinase 1A	DEG_SPOP_SBC_1	63:67	ALSSS	SPOP	0.9976	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	1625:1629	ALSSS	SPOP	0.9778	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	273:277	ALSSS	SPOP	0.9986	More...
Q52LR7	Enhancer of polycomb homolog 2	DEG_SPOP_SBC_1	684:688	ALSSS	SPOP	0.9033	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	320:324	ALSSS	SPOP	0.9947	More...
Q8IXT1	DNA damage-induced apoptosis suppressor protein	DEG_SPOP_SBC_1	541:545	ALSSS	SPOP	0.9938	More...
Q9H2A3	Neurogenin-2	DEG_SPOP_SBC_1	200:204	ALSSS	SPOP	0.923	More...
Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	DEG_SPOP_SBC_1	409:413	ALSSS	SPOP	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALSSS

Degron related mutations and impact score

Drug responses associated with RAF1 mutations

All proteins holding degron of ALSSS