DegronMD - Q8IZC6(COL27A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P365T	TCGA-36-2534	OV	TCGA	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0833
p.P365T	DO29046	OV	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0833
p.T370S	TCGA-44-7660	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2222
p.T370S	DO23834	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2222
p.G970V	TCGA-50-5930	LUAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6421
p.G970V	DO25189	LUAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6421
p.R965M	TCGA-55-6979	LUAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1944
p.R965M	DO24110	LUAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1944
p.A374S	TCGA-55-7574	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	374:378	Mutation altering degron motif	0.7588
p.A374S	DO23986	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation altering degron motif	0.7588
p.P987L	TCGA-5M-AAT6	COAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.0833
p.P987L	DO223703	COAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.0833
p.V523A	TCGA-63-A5MM	LUSC	TCGA	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation altering degron motif	0.6936
p.V523A	DO219153	LUSC	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation altering degron motif	0.6936
p.S1670C	TCGA-63-A5MW	LUSC	TCGA	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.1667
p.S1670C	DO219169	LUSC	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.1667
p.R986Q	TCGA-96-7544	LUSC	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111
p.R986Q	DO26425	LUSC	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111
p.R986W	TCGA-AA-A00N	COAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111
p.R986W	DO9876	COAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111
p.V1431M	TCGA-AP-A1DV	UCEC	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.2778
p.V1431M	DO43186	UCEC	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.2778
p.A1441T	TCGA-AX-A1CE	UCEC	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.6028
p.A1441T	TCGA-AX-A2HD	UCEC	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.6028
p.A1441T	DO42280	UCEC	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.6028
p.A1441T	DO42608	UCEC	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation altering degron motif	0.6028
p.L1425P	TCGA-AZ-6598	COAD	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.1111
p.L1425P	DO10276	COAD	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.1111
p.D263N	TCGA-B5-A0K8	UCEC	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.2222
p.D263N	TCGA-DF-A2KU	UCEC	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.2222
p.D263N	DO40831	UCEC	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.2222
p.D263N	DO223286	UCEC	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.2222
p.F250L	TCGA-BR-4357	STAD	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.25
p.F250L	DO38241	STAD	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.25
p.K535R	TCGA-BR-8361	STAD	TCGA	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation substituting flanking lysine	0.1944
p.K535R	DO48032	STAD	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation substituting flanking lysine	0.1944
p.R1688W	TCGA-BR-A4QL	STAD	TCGA	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.1667
p.R1688W	DO38723	STAD	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.1667
p.G976V	TCGA-CR-7364	HNSC	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6421
p.G976V	DO15679	HNSC	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6421
p.L1672F	TCGA-D3-A5GR	SKCM	TCGA	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.2222
p.L1672F	DO47436	SKCM	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.2222
p.Q252K	TCGA-D9-A148	SKCM	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.3056
p.Q252K	DO37971	SKCM	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.3056
p.P969L	TCGA-DA-A1HV	SKCM	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.3056
p.P969L	DO37659	SKCM	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.3056
p.R1429W	TCGA-DM-A1HB	COAD	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.2222
p.R1429W	TCGA-KL-8329	KICH	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.2222
p.R1429W	DO233913	GACA	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.2222
p.R1429W	DO220337	KICH	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.2222
p.R1691M	TCGA-EE-A181	SKCM	TCGA	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.0833
p.R1691M	DO37444	SKCM	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.0833
p.P510Q	TCGA-EE-A184	SKCM	TCGA	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.2222
p.P510Q	DO47442	SKCM	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.2222
p.P969H	TCGA-ER-A19P	SKCM	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.3056
p.P969H	DO47623	SKCM	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.3056
p.H386N	TCGA-F4-6703	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1111
p.H386N	DO9908	COAD	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1111
p.Q1674P	TCGA-F5-6814	READ	TCGA	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.2778
p.Q1674P	DO36556	READ	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.2778
p.Q261H	TCGA-FS-A1ZG	SKCM	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.2778
p.Q261H	DO37523	SKCM	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.2778
p.S489L	TCGA-H4-A2HQ	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	DO522	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.G964D	TCGA-HD-A6HZ	HNSC	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1667
p.G964D	DO49998	HNSC	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1667
p.G964D	SIDM00217	Colorectal Carcinoma	GDSC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1667
p.G964D	ACH-000999	Colon/Colorectal Cancer	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1667
p.G964D	SNU-1040	large intestine	COSMIC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1667
p.Q962H	TCGA-HT-A61C	LGG	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111
p.Q962H	DO219813	LGG	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111
p.V977M	TCGA-NH-A5IV	COAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6097
p.V977M	DO49095	COAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6097
p.G976D	TCGA-VQ-A8P2	STAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6087
p.G976D	DO51761	STAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation altering degron motif	0.6087
p.L1680R	DO8264	COAD	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation altering degron motif	0.7316
p.S373L	DO222798	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.3056
p.I379F	DO229016	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.3056
p.T388I	DO229005	COCA	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.T388I	SIDM01019	Acute Myeloid Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.T388I	SIDM01498	Acute Myeloid Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.T388I	SIDM01320	Pancreatic Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.T388I	SIDM00160	Biliary Tract Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.T388I	SIDM01391	Neuroblastoma	GDSC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.T388I	SIDM01729	Endometrial Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.I1673T	DO228761	GACA	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.25
p.S244F	DO228971	LICA	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.0833
p.V508L	DO229036	LICA	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.1667
p.V508L	DO229036	LICA	ICGC	PAPTPGST	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.0556
p.S477I	DO229036	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.S378L	DO220872	MELA	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation altering degron motif	0.7667
p.LP368LS	DO222843	MELA	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0
p.K1683E	DO51520	PACA	ICGC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.3056
p.I364V	DO229459	SKCA	ICGC	APSTS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0556
p.G1424R	DO229491	SKCA	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	1433:1441	Mutation rewiring degron network	0.0833
p.A265T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.1667
p.A265T	SIDM00875	Breast Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.1667
p.A265T	SIDM00793	Burkitt's Lymphoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.1667
p.A265T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.1667
p.A265T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.1667
p.I1673N	SIDM00501	Oral Cavity Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.25
p.I1673N	ACH-001332	Head and Neck Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.25
p.I1673N	BICR78	upper aerodigestive tract	COSMIC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.25
p.G988W	SIDM00120	Prostate Carcinoma	GDSC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.0556
p.G988W	ACH-000979	Prostate Cancer	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.0556
p.G988W	DU-145	prostate	COSMIC	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.0556
p.I1673V	SIDM00789	Colorectal Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.25
p.I1673V	ACH-000997	Colon/Colorectal Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.25
p.I1673V	HCT-15	large intestine	COSMIC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.25
p.P437L	SIDM00650	Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1389
p.P437L	SIDM01681	Non-Cancerous	GDSC	PPTTS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.1389
p.T506M	SIDM00576	Acute Myeloid Leukemia	GDSC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.1111
p.T506M	SIDM00576	Acute Myeloid Leukemia	GDSC	PAPTPGST	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1111
p.T506M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.1111
p.T506M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PAPTPGST	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1111
p.T506M	ACH-000891	Lung Cancer	CCLE	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.1111
p.T506M	ACH-000891	Lung Cancer	CCLE	PAPTPGST	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1111
p.T506M	ACH-002290	Leukemia	CCLE	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.1111
p.T506M	ACH-002290	Leukemia	CCLE	PAPTPGST	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1111
p.T506M	NKM-1	haematopoietic and lymphoid tissue	COSMIC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation rewiring degron network	0.1111
p.T506M	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PAPTPGST	DEG_SCF_FBW7_1	491:498	Mutation rewiring degron network	0.1111
p.S262Y	SIDM00793	Burkitt's Lymphoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.25
p.S262Y	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.25
p.S262Y	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.25
p.R1688Q	SIDM01397	Melanoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.1667
p.R1688Q	SIDM01619	Endometrial Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.1667
p.V523I	SIDM01472	Hepatocellular Carcinoma	GDSC	TSTPRTAPAVPTP	DEG_COP1_1	514:526	Mutation altering degron motif	0.7076
p.Q243H	SIDM01413	Oral Cavity Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.0556
p.Q243H	ACH-000630	Head and Neck Cancer	CCLE	DSGRPFT	DEG_SCF_TRCP1_1	253:259	Mutation rewiring degron network	0.0556
p.I1676M	SIDM01588	Endometrial Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation altering degron motif	0.6507
p.I1676M	ACH-000993	Endometrial/Uterine Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation altering degron motif	0.6507
p.R986P	ACH-000526	Non-Cancerous	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111
p.S1675N	ACH-001375	Pancreatic Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	1676:1682	Mutation rewiring degron network	0.3056
p.R986L	ACH-001607	Gallbladder Cancer	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	970:978	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL27A1

UniProt ID: Q8IZC6

Entrez ID: 85301

Protein name: Collagen alpha-1(XXVII) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL27A1 in