DegronMD

Uniprot ID: Q8IZC6

Source protein: Collagen alpha-1

Source gene: COL27A1

Class: DEG_SCF_TRCP1_1

Location: 253:259

E3 ligase: BTRC

DEGRON score: 0.9768

ASA_SCORE: 72.3571

COIL: 0.8296

CONS_SCORE: 0.2333

DSS_SCORE: 0.3711

HELIX: 0.0531

FCONS_SCORE: 0.9727

RIG_SCORE: 0.7149

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D263N	TCGA-B5-A0K8	UCEC	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	0.2222
p.D263N	TCGA-DF-A2KU	UCEC	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	0.2222
p.D263N	DO40831	UCEC	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	0.2222
p.D263N	DO223286	UCEC	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	0.2222
p.F250L	TCGA-BR-4357	STAD	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	0.25
p.F250L	DO38241	STAD	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	0.25
p.Q252K	TCGA-D9-A148	SKCM	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	0.3056
p.Q252K	DO37971	SKCM	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	0.3056
p.Q261H	TCGA-FS-A1ZG	SKCM	TCGA	DSGRPFT	DEG_SCF_TRCP1_1	0.2778
p.Q261H	DO37523	SKCM	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	0.2778
p.S244F	DO228971	LICA	ICGC	DSGRPFT	DEG_SCF_TRCP1_1	0.0833
p.A265T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.1667
p.A265T	SIDM00875	Breast Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.1667
p.A265T	SIDM00793	Burkitt's Lymphoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.1667
p.A265T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.1667
p.A265T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.1667
p.S262Y	SIDM00793	Burkitt's Lymphoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.25
p.S262Y	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.25
p.S262Y	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.25
p.Q243H	SIDM01413	Oral Cavity Carcinoma	GDSC	DSGRPFT	DEG_SCF_TRCP1_1	0.0556
p.Q243H	ACH-000630	Head and Neck Cancer	CCLE	DSGRPFT	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZC6	Collagen alpha-1	DEG_SCF_TRCP1_1	253:259	DSGRPFT	BTRC	0.9768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons