DegronMD

Uniprot ID: Q8IZC6

Source protein: Collagen alpha-1

Source gene: COL27A1

Class: DEG_COP1_1

Location: 514:526

E3 ligase: COP1

DEGRON score: 0.9663

ASA_SCORE: 79.0385

COIL: 0.9498

CONS_SCORE: 0.1922

DSS_SCORE: 0.76

HELIX: 0.0128

FCONS_SCORE: -0.0042

RIG_SCORE: 0.587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V523A	TCGA-63-A5MM	LUSC	TCGA	TSTPRTAPAVPTP	DEG_COP1_1	0.6936
p.V523A	DO219153	LUSC	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	0.6936
p.K535R	TCGA-BR-8361	STAD	TCGA	TSTPRTAPAVPTP	DEG_COP1_1	0.1944
p.K535R	DO48032	STAD	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	0.1944
p.P510Q	TCGA-EE-A184	SKCM	TCGA	TSTPRTAPAVPTP	DEG_COP1_1	0.2222
p.P510Q	DO47442	SKCM	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	0.2222
p.V508L	DO229036	LICA	ICGC	TSTPRTAPAVPTP	DEG_COP1_1	0.1667
p.T506M	SIDM00576	Acute Myeloid Leukemia	GDSC	TSTPRTAPAVPTP	DEG_COP1_1	0.1111
p.T506M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	TSTPRTAPAVPTP	DEG_COP1_1	0.1111
p.T506M	ACH-000891	Lung Cancer	CCLE	TSTPRTAPAVPTP	DEG_COP1_1	0.1111
p.T506M	ACH-002290	Leukemia	CCLE	TSTPRTAPAVPTP	DEG_COP1_1	0.1111
p.T506M	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	TSTPRTAPAVPTP	DEG_COP1_1	0.1111
p.V523I	SIDM01472	Hepatocellular Carcinoma	GDSC	TSTPRTAPAVPTP	DEG_COP1_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZC6	Collagen alpha-1	DEG_COP1_1	514:526	TSTPRTAPAVPTP	COP1	0.9663	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons