DegronMD

Uniprot ID: Q8IZC6

Source protein: Collagen alpha-1

Source gene: COL27A1

Class: DEG_SCF_FBW7_1

Location: 491:498

E3 ligase: FBXW7

DEGRON score: 0.9736

ASA_SCORE: 77.05

COIL: 0.9411

CONS_SCORE: -124.8262

DSS_SCORE: 0.763

HELIX: 0.0116

FCONS_SCORE: 0.9167

RIG_SCORE: 0.4882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V508L	DO229036	LICA	ICGC	PAPTPGST	DEG_SCF_FBW7_1	0.0556
p.T506M	SIDM00576	Acute Myeloid Leukemia	GDSC	PAPTPGST	DEG_SCF_FBW7_1	0.1111
p.T506M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PAPTPGST	DEG_SCF_FBW7_1	0.1111
p.T506M	ACH-000891	Lung Cancer	CCLE	PAPTPGST	DEG_SCF_FBW7_1	0.1111
p.T506M	ACH-002290	Leukemia	CCLE	PAPTPGST	DEG_SCF_FBW7_1	0.1111
p.T506M	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PAPTPGST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZC6	Collagen alpha-1	DEG_SCF_FBW7_1	491:498	PAPTPGST	FBXW7	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons