DegronMD

Uniprot ID: Q8IZC6

Source protein: Collagen alpha-1

Source gene: COL27A1

Class: DEG_APCC_DBOX_1

Location: 970:978

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9862

ASA_SCORE: 78.2556

COIL: 0.9441

CONS_SCORE: 0.574

DSS_SCORE: 0.8189

HELIX: 0.0139

FCONS_SCORE: 1.0422

RIG_SCORE: 0.5809

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G970V	TCGA-50-5930	LUAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.6421
p.G970V	DO25189	LUAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.6421
p.R965M	TCGA-55-6979	LUAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.1944
p.R965M	DO24110	LUAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.1944
p.P987L	TCGA-5M-AAT6	COAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.0833
p.P987L	DO223703	COAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.0833
p.R986Q	TCGA-96-7544	LUSC	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111
p.R986Q	DO26425	LUSC	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111
p.R986W	TCGA-AA-A00N	COAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111
p.R986W	DO9876	COAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111
p.G976V	TCGA-CR-7364	HNSC	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.6421
p.G976V	DO15679	HNSC	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.6421
p.P969L	TCGA-DA-A1HV	SKCM	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.3056
p.P969L	DO37659	SKCM	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.3056
p.P969H	TCGA-ER-A19P	SKCM	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.3056
p.P969H	DO47623	SKCM	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.3056
p.G964D	TCGA-HD-A6HZ	HNSC	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.1667
p.G964D	DO49998	HNSC	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.1667
p.G964D	SIDM00217	Colorectal Carcinoma	GDSC	GRPGLDGVK	DEG_APCC_DBOX_1	0.1667
p.G964D	ACH-000999	Colon/Colorectal Cancer	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	0.1667
p.G964D	SNU-1040	large_intestine	COSMIC	GRPGLDGVK	DEG_APCC_DBOX_1	0.1667
p.Q962H	TCGA-HT-A61C	LGG	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111
p.Q962H	DO219813	LGG	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111
p.V977M	TCGA-NH-A5IV	COAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.6097
p.V977M	DO49095	COAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.6097
p.G976D	TCGA-VQ-A8P2	STAD	TCGA	GRPGLDGVK	DEG_APCC_DBOX_1	0.6087
p.G976D	DO51761	STAD	ICGC	GRPGLDGVK	DEG_APCC_DBOX_1	0.6087
p.G988W	SIDM00120	Prostate Carcinoma	GDSC	GRPGLDGVK	DEG_APCC_DBOX_1	0.0556
p.G988W	ACH-000979	Prostate Cancer	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	0.0556
p.G988W	DU-145	prostate	COSMIC	GRPGLDGVK	DEG_APCC_DBOX_1	0.0556
p.R986P	ACH-000526	Non-Cancerous	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111
p.R986L	ACH-001607	Gallbladder Cancer	CCLE	GRPGLDGVK	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPGLDGVK

Degron related mutations and impact score

Drug responses associated with COL27A1 mutations

All proteins holding degron of GRPGLDGVK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZC6	Collagen alpha-1	DEG_APCC_DBOX_1	970:978	GRPGLDGVK	APC,CDC20,FZR1	0.9862	More...