DegronMD

Uniprot ID: Q8IZC6

Source protein: Collagen alpha-1

Source gene: COL27A1

Class: DEG_APCC_DBOX_1

Location: 1433:1441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9471

ASA_SCORE: 75.2222

COIL: 0.9242

CONS_SCORE: 0.379

DSS_SCORE: 0.7057

HELIX: 0.0187

FCONS_SCORE: 0.9822

RIG_SCORE: 0.6626

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1431M	TCGA-AP-A1DV	UCEC	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	0.2778
p.V1431M	DO43186	UCEC	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	0.2778
p.A1441T	TCGA-AX-A1CE	UCEC	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	0.6028
p.A1441T	TCGA-AX-A2HD	UCEC	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	0.6028
p.A1441T	DO42280	UCEC	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	0.6028
p.A1441T	DO42608	UCEC	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	0.6028
p.L1425P	TCGA-AZ-6598	COAD	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	0.1111
p.L1425P	DO10276	COAD	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	0.1111
p.R1429W	TCGA-DM-A1HB	COAD	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	0.2222
p.R1429W	TCGA-KL-8329	KICH	TCGA	GRQGLEGIA	DEG_APCC_DBOX_1	0.2222
p.R1429W	DO233913	GACA	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	0.2222
p.R1429W	DO220337	KICH	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	0.2222
p.G1424R	DO229491	SKCA	ICGC	GRQGLEGIA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZC6	Collagen alpha-1	DEG_APCC_DBOX_1	1433:1441	GRQGLEGIA	APC,CDC20,FZR1	0.9471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons