DegronMD

Uniprot ID: Q8IZC6

Source protein: Collagen alpha-1

Source gene: COL27A1

Class: DEG_SCF_FBW7_1

Location: 1676:1682

E3 ligase: FBXW7

DEGRON score: 0.6962

ASA_SCORE: 51.7

COIL: 0.8739

CONS_SCORE: 0.5749

DSS_SCORE: 0.2849

HELIX: 0.0757

FCONS_SCORE: 1.1176

RIG_SCORE: 0.7529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1670C	TCGA-63-A5MW	LUSC	TCGA	IKTPLGT	DEG_SCF_FBW7_1	0.1667
p.S1670C	DO219169	LUSC	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.1667
p.R1688W	TCGA-BR-A4QL	STAD	TCGA	IKTPLGT	DEG_SCF_FBW7_1	0.1667
p.R1688W	DO38723	STAD	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.1667
p.L1672F	TCGA-D3-A5GR	SKCM	TCGA	IKTPLGT	DEG_SCF_FBW7_1	0.2222
p.L1672F	DO47436	SKCM	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.2222
p.R1691M	TCGA-EE-A181	SKCM	TCGA	IKTPLGT	DEG_SCF_FBW7_1	0.0833
p.R1691M	DO37444	SKCM	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.0833
p.Q1674P	TCGA-F5-6814	READ	TCGA	IKTPLGT	DEG_SCF_FBW7_1	0.2778
p.Q1674P	DO36556	READ	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.2778
p.L1680R	DO8264	COAD	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.7316
p.I1673T	DO228761	GACA	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.25
p.K1683E	DO51520	PACA	ICGC	IKTPLGT	DEG_SCF_FBW7_1	0.3056
p.I1673N	SIDM00501	Oral Cavity Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	0.25
p.I1673N	ACH-001332	Head and Neck Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	0.25
p.I1673N	BICR78	upper_aerodigestive_tract	COSMIC	IKTPLGT	DEG_SCF_FBW7_1	0.25
p.I1673V	SIDM00789	Colorectal Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	0.25
p.I1673V	ACH-000997	Colon/Colorectal Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	0.25
p.I1673V	HCT-15	large_intestine	COSMIC	IKTPLGT	DEG_SCF_FBW7_1	0.25
p.R1688Q	SIDM01397	Melanoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	0.1667
p.R1688Q	SIDM01619	Endometrial Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	0.1667
p.I1676M	SIDM01588	Endometrial Carcinoma	GDSC	IKTPLGT	DEG_SCF_FBW7_1	0.6507
p.I1676M	ACH-000993	Endometrial/Uterine Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	0.6507
p.S1675N	ACH-001375	Pancreatic Cancer	CCLE	IKTPLGT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZC6	Collagen alpha-1	DEG_SCF_FBW7_1	1676:1682	IKTPLGT	FBXW7	0.6962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons